Seroatlas · Human Serome Atlas

LCE3A

Late cornified envelope protein 3A

Also known as: LCE3A_HUMAN, LEP13

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5TA76
Gene
LCE3A
Ensembl
ENSG00000185962
Chromosome
1
Canonical length
89 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and killing of cells of another organism. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

89 residues, UniProt reviewed canonical sequence.

>Q5TA76|LCE3A
     1  MSCQQNQQQC QPPPKCPAKS PAQCLPPASS SCAPSSGGCG PSSERSCCLS HHRCRRSHRC
    61  RCQSSNSCDR GSGQQGGSSS CGHSSAGCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LCE3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.74
Highest tissue expression
101 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 101 nTPM
  • vagina: 8.2 nTPM
  • cervix: 7.1 nTPM
  • esophagus: 3.8 nTPM
  • skin: 2.5 nTPM
  • salivary gland: 1.2 nTPM

Single-cell type

  • early spermatids: 3.5 nCPM
  • early primary spermatocytes: 2.7 nCPM
  • late spermatids: 2.6 nCPM
  • esophageal apical cells: 1.3 nCPM
  • differentiating spermatogonia: 1.1 nCPM
  • undifferentiated spermatogonia: 1 nCPM

Immune cell

  • plasmacytoid DC: 0.8 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • pons: 0.1 nTPM
  • cerebellum: 0 nTPM
  • choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
-0.26
DepMap mean gene effect
-0.34
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LCE3A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LCE3A as an antibody target. Whether an autoantibody or antibody against LCE3A could matter depends on whether native LCE3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LCE3A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LCE3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LCE3A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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