LCE1A
Late cornified envelope protein 1A
Also known as: LCE1A_HUMAN, LEP1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5T7P2
- Gene
- LCE1A
- Ensembl
- ENSG00000186844
- Chromosome
- 1
- Canonical length
- 110 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
LCE1A belongs to the late cornified envelope (LCE) gene cluster within the epidermal differentiation complex (EDC) on chromosome 1. The LCE cluster contains multiple conserved genes that encode stratum corneum proteins, and these genes are expressed relatively late during fetal assembly of the skin cornified envelope (Jackson et al., 2005 [PubMed 15854049]). For further information on the LCE gene cluster, see GENE FAMILY below.[supplied by OMIM, Feb 2009]
Canonical amino-acid sequenceUniProt
110 residues, UniProt reviewed canonical sequence.
>Q5T7P2|LCE1A
1 MSCQQSQQQC QPPPKCTPKC PPKCPTPKCP PKCPPKCPPV SSCCSVSSGG CCGSSSGGGC
61 SSGGGGCCLS HHRRHRSHRH RLQSSGCCSQ PSGGSSCCGG DSGQHSGGCCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LCE1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.75
- Highest tissue expression
- 379 nTPM
Expression across tissuesHPA
Tissue
- skin: 379 nTPM
- breast: 22 nTPM
- skeletal muscle: 2.9 nTPM
- cervix: 1.1 nTPM
- spinal cord: 0.9 nTPM
- salivary gland: 0.4 nTPM
Single-cell type
- late spermatids: 1.1 nCPM
- cdc: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- medulla oblongata: 0.4 nTPM
- white matter: 0.4 nTPM
- midbrain: 0.3 nTPM
- cerebellum: 0.2 nTPM
- pons: 0.1 nTPM
- amygdala: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.91
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.52
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of LCE1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LCE1A as an antibody target. Whether an autoantibody or antibody against LCE1A could matter depends on whether native LCE1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LCE1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LCE1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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