Seroatlas · Human Serome Atlas

DCSTAMP

Dendritic cell-specific transmembrane protein

Also known as: DC-STAMP, DCSTP_HUMAN, FIND, TM7SF4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H295
Gene
DCSTAMP
Ensembl
ENSG00000164935
Chromosome
8
Canonical length
470 aa
Protein class
Predicted membrane proteins, Transporters
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

470 residues, UniProt reviewed canonical sequence.

>Q9H295|DCSTAMP
     1  MGIWTSGTDI FLSLWEIYVS PRSPGWMDFI QHLGVCCLVA LISVGLLSVA ACWFLPSIIA
    61  AAASWIITCV LLCCSKHARC FILLVFLSCG LREGRNALIA AGTGIVILGH VENIFHNFKG
   121  LLDGMTCNLR AKSFSIHFPL LKKYIEAIQW IYGLATPLSV FDDLVSWNQT LAVSLFSPSH
   181  VLEAQLNDSK GEVLSVLYQM ATTTEVLSSL GQKLLAFAGL SLVLLGTGLF MKRFLGPCGW
   241  KYENIYITRQ FVQFDERERH QQRPCVLPLN KEERRKYVII PTFWPTPKER KNLGLFFLPI
   301  LIHLCIWVLF AAVDYLLYRL IFSVSKQFQS LPGFEVHLKL HGEKQGTQDI IHDSSFNISV
   361  FEPNCIPKPK FLLSETWVPL SVILLILVML GLLSSILMQL KILVSASFYP SVERKRIQYL
   421  HAKLLKKRSK QPLGEVKRRL SLYLTKIHFW LPVLKMIRKK QMDMASADKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCSTAMP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
3.5 nTPM

Expression across tissuesHPA

Tissue

  • lung: 3.5 nTPM
  • epididymis: 1.8 nTPM
  • amygdala: 0.9 nTPM
  • adipose tissue: 0.8 nTPM
  • breast: 0.3 nTPM
  • liver: 0.3 nTPM

Single-cell type

  • macrophages: 14 nCPM
  • monocytes: 5.8 nCPM
  • platelets: 4.2 nCPM
  • hematopoietic stem cells: 2.4 nCPM
  • brain excitatory neurons: 1 nCPM
  • kupffer cells: 1 nCPM

Immune cell

  • non-classical monocyte: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • amygdala: 9.9 nTPM
  • cerebral cortex: 6.2 nTPM
  • thalamus: 2.6 nTPM
  • hippocampal formation: 2.1 nTPM
  • hypothalamus: 1.3 nTPM
  • white matter: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.16
gnomAD pLI
0
gnomAD missense Z
0.36
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCSTAMP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCSTAMP as an antibody target. Whether an autoantibody or antibody against DCSTAMP could matter depends on whether native DCSTAMP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCSTAMP is annotated at the cell surface, where native DCSTAMP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DCSTAMP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DCSTAMP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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