Seroatlas · Human Serome Atlas

SLC35C2

Solute carrier family 35 member C2

Also known as: bA394O2.1, C20orf5, CGI-15, OVCOV1, S35C2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQQ7
Gene: SLC35C2
Ensembl: ENSG00000080189
Chromosome: 20
Canonical length: 365 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

This gene encodes a member of the triose-phosphate transporter protein family. This gene is regulated by oxygen tension, is induced in hypoxic trophoblast cells, and is overexpressed in ovarian cancer. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

365 residues, UniProt reviewed canonical sequence.

>Q9NQQ7|SLC35C2
     1  MGRWALDVAF LWKAVLTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM LHLAVIFLFS
    61  ALSRALVQCS SHRARVVLSW ADYLRRVAPT ALATALDVGL SNWSFLYVTV SLYTMTKSSA
   121  VLFILIFSLI FKLEELRAAL VLVVLLIAGG LFMFTYKSTQ FNVEGFALVL GASFIGGIRW
   181  TLTQMLLQKA ELGLQNPIDT MFHLQPLMFL GLFPLFAVFE GLHLSTSEKI FRFQDTGLLL
   241  RVLGSLFLGG ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW
   301  LGFALCLSGI SLHVALKALH SRGDGGPKAL KGLGSSPDLE LLLRSSQREE GDNEEEEYFV
   361  AQGQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35C2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

liver: 35 nTPM
adrenal gland: 33 nTPM
choroid plexus: 33 nTPM
pancreas: 31 nTPM
spleen: 30 nTPM
skin: 29 nTPM

Single-cell type

breast lactating cells: 144 nCPM
cytotrophoblasts: 123 nCPM
neutrophil progenitors: 108 nCPM
epididymal principal cells: 103 nCPM
syncytiotrophoblasts: 96 nCPM
migrating cytotrophoblasts: 91 nCPM

Immune cell

plasmacytoid DC: 73 nTPM
eosinophil: 48 nTPM
naive CD4 T-cell: 45 nTPM
total PBMC: 44 nTPM
basophil: 43 nTPM
myeloid DC: 43 nTPM

Brain region

thalamus: 23 nTPM
midbrain: 23 nTPM
amygdala: 22 nTPM
medulla oblongata: 21 nTPM
choroid plexus: 21 nTPM
pons: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 1.23
DepMap mean gene effect: 0.1
DepMap dependency class: none

OntologyGO

Biological processes

Molecular functions

antiporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC35C2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CREB3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35C2 as an antibody target. Whether an autoantibody or antibody against SLC35C2 could matter depends on whether native SLC35C2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35C2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35C2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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