CCR1
C-C chemokine receptor type 1
Also known as: CCR1_HUMAN, CD191, CKR-1, CMKBR1, MIP1aR, SCYAR1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P32246
- Gene
- CCR1
- Ensembl
- ENSG00000163823
- Chromosome
- 3
- Canonical length
- 355 aa
- Protein class
- CD markers, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins
OverviewNCBI Gene
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
355 residues, UniProt reviewed canonical sequence.
>P32246|CCR1
1 METPNTTEDY DTTTEFDYGD ATPCQKVNER AFGAQLLPPL YSLVFVIGLV GNILVVLVLV
61 QYKRLKNMTS IYLLNLAISD LLFLFTLPFW IDYKLKDDWV FGDAMCKILS GFYYTGLYSE
121 IFFIILLTID RYLAIVHAVF ALRARTVTFG VITSIIIWAL AILASMPGLY FSKTQWEFTH
181 HTCSLHFPHE SLREWKLFQA LKLNLFGLVL PLLVMIICYT GIIKILLRRP NEKKSKAVRL
241 IFVIMIIFFL FWTPYNLTIL ISVFQDFLFT HECEQSRHLD LAVQVTEVIA YTHCCVNPVI
301 YAFVGERFRK YLRQLFHRRV AVHLVKWLPF LSVDRLERVS STSPSTGEHE LSAGFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CCR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 40 nTPM
Expression across tissuesHPA
Tissue
- appendix: 40 nTPM
- spleen: 29 nTPM
- placenta: 25 nTPM
- bone marrow: 23 nTPM
- adipose tissue: 20 nTPM
- lung: 18 nTPM
Single-cell type
- kupffer cells: 283 nCPM
- hofbauer cells: 202 nCPM
- monocytes: 141 nCPM
- extravillous trophoblasts: 127 nCPM
- macrophages: 93 nCPM
- neutrophils: 63 nCPM
Immune cell
- classical monocyte: 125 nTPM
- neutrophil: 114 nTPM
- NK-cell: 85 nTPM
- basophil: 83 nTPM
- intermediate monocyte: 76 nTPM
- myeloid DC: 54 nTPM
Brain region
- white matter: 14 nTPM
- medulla oblongata: 9.3 nTPM
- thalamus: 9.3 nTPM
- spinal cord: 8.4 nTPM
- pons: 6.9 nTPM
- midbrain: 5.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.69
- gnomAD pLI
- 0.39
- gnomAD missense Z
- 1.17
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- calcium ion transport
- calcium-mediated signaling
- cell adhesion
- cell chemotaxis
- cell surface receptor signaling pathway
- cell-cell signaling
- chemokine-mediated signaling pathway
- chemotaxis
- cytokine-mediated signaling pathway
- dendritic cell chemotaxis
- exocytosis
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- immune response
- inflammatory response
- intracellular calcium ion homeostasis
- monocyte chemotaxis
- negative regulation of bone mineralization
- negative regulation of gene expression
- positive regulation of calcium ion transport
- positive regulation of cell migration
- positive regulation of cytosolic calcium ion concentration
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of inflammatory response
- positive regulation of monocyte chemotaxis
- positive regulation of neuroinflammatory response
- positive regulation of osteoclast differentiation
- response to wounding
Molecular functions
- C-C chemokine binding
- C-C chemokine receptor activity
- chemokine (C-C motif) ligand 5 binding
- chemokine (C-C motif) ligand 7 binding
- chemokine receptor activity
- phosphatidylinositol-4,5-bisphosphate phospholipase C activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CCR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CCR1 as an antibody target. Whether an autoantibody or antibody against CCR1 could matter depends on whether native CCR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CCR1 is annotated at the cell surface, where native CCR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label CCR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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