Seroatlas · Human Serome Atlas

TOX4

TOX high mobility group box family member 4

Also known as: C14orf92, KIAA0737, LCP1, TOX4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94842
Gene: TOX4
Ensembl: ENSG00000092203
Chromosome: 14
Canonical length: 621 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable chromatin DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in chromatin and chromosome, telomeric region. Part of PTW/PP1 phosphatase complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

621 residues, UniProt reviewed canonical sequence.

>O94842|TOX4
     1  MEFPGGNDNY LTITGPSHPF LSGAETFHTP SLGDEEFEIP PISLDSDPSL AVSDVVGHFD
    61  DLADPSSSQD GSFSAQYGVQ TLDMPVGMTH GLMEQGGGLL SGGLTMDLDH SIGTQYSANP
   121  PVTIDVPMTD MTSGLMGHSQ LTTIDQSELS SQLGLSLGGG TILPPAQSPE DRLSTTPSPT
   181  SSLHEDGVED FRRQLPSQKT VVVEAGKKQK APKKRKKKDP NEPQKPVSAY ALFFRDTQAA
   241  IKGQNPNATF GEVSKIVASM WDSLGEEQKQ VYKRKTEAAK KEYLKALAAY KDNQECQATV
   301  ETVELDPAPP SQTPSPPPMA TVDPASPAPA SIEPPALSPS IVVNSTLSSY VANQASSGAG
   361  GQPNITKLII TKQMLPSSIT MSQGGMVTVI PATVVTSRGL QLGQTSTATI QPSQQAQIVT
   421  RSVLQAAAAA AAAASMQLPP PRLQPPPLQQ MPQPPTQQQV TILQQPPPLQ AMQQPPPQKV
   481  RINLQQQPPP LQIKSVPLPT LKMQTTLVPP TVESSPERPM NNSPEAHTVE APSPETICEM
   541  ITDVVPEVES PSQMDVELVS GSPVALSPQP RCVRSGCENP PIVSKDWDNE YCSNECVVKH
   601  CRDVFLAWVA SRNSNTVVFV K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOX4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 51 nTPM
thymus: 24 nTPM
tongue: 24 nTPM
heart muscle: 21 nTPM
blood vessel: 21 nTPM
bone marrow: 20 nTPM

Single-cell type

syncytiotrophoblasts: 380 nCPM
esophageal apical cells: 242 nCPM
neutrophils: 159 nCPM
late primary spermatocytes: 145 nCPM
oocytes: 143 nCPM
esophageal suprabasal cells: 121 nCPM

Immune cell

neutrophil: 49 nTPM
basophil: 41 nTPM
eosinophil: 40 nTPM
plasmacytoid DC: 34 nTPM
T-reg: 32 nTPM
intermediate monocyte: 29 nTPM

Brain region

midbrain: 31 nTPM
white matter: 31 nTPM
thalamus: 30 nTPM
cerebral cortex: 29 nTPM
cerebellum: 28 nTPM
hypothalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.96
gnomAD missense Z: 2.37
DepMap mean gene effect: -0.37
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

chromatin DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TOX4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TOX4 as an antibody target. Whether an autoantibody or antibody against TOX4 could matter depends on whether native TOX4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TOX4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TOX4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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