TRIB1

Protein identityUniProt · HPA

UniProt accession

Q96RU8

Gene

TRIB1

Ensembl

ENSG00000173334

Chromosome

8

Canonical length

372 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Plasma membrane,Cytosol

OverviewNCBI Gene

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; mitogen-activated protein kinase kinase binding activity; and protein kinase inhibitor activity. Involved in several processes, including JNK cascade; negative regulation of lipopolysaccharide-mediated signaling pathway; and regulation of protein kinase activity. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

372 residues, UniProt reviewed canonical sequence.

>Q96RU8|TRIB1
     1  MRVGPVRSAM SGASQPRGPA LLFPATRGVP AKRLLDADDA AAVAAKCPRL SECSSPPDYL
    61  SPPGSPCSPQ PPPAAPGAGG GSGSAPGPSR IADYLLLPLA EREHVSRALC IHTGRELRCK
   121  VFPIKHYQDK IRPYIQLPSH SNITGIVEVI LGETKAYVFF EKDFGDMHSY VRSRKRLREE
   181  EAARLFKQIV SAVAHCHQSA IVLGDLKLRK FVFSTEERTQ LRLESLEDTH IMKGEDDALS
   241  DKHGCPAYVS PEILNTTGTY SGKAADVWSL GVMLYTLLVG RYPFHDSDPS ALFSKIRRGQ
   301  FCIPEHISPK ARCLIRSLLR REPSERLTAP EILLHPWFES VLEPGYIDSE IGTSDQIVPE
   361  YQEDSDISSF FC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

346 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRIB1.

Disease | ImmuneIEDB

Conditions an epitope on TRIB1 was assayed in.

• narcolepsy T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.46

gnomAD pLI

0.83

gnomAD missense Z

1.21

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of JNK cascade
• negative regulation of lipopolysaccharide-mediated signaling pathway
• negative regulation of MAPK cascade
• negative regulation of neutrophil differentiation
• negative regulation of smooth muscle cell migration
• negative regulation of smooth muscle cell proliferation
• negative regulation of transcription by RNA polymerase II
• positive regulation of eosinophil differentiation
• positive regulation of macrophage differentiation
• positive regulation of proteasomal ubiquitin-dependent protein catabolic process
• regulation of MAP kinase activity
• response to lipopolysaccharide

Molecular functions

• mitogen-activated protein kinase kinase binding
• protein kinase binding
• protein kinase inhibitor activity
• RNA polymerase II-specific DNA-binding transcription factor binding
• transcription regulator inhibitor activity
• ubiquitin protein ligase binding
• ubiquitin-protein transferase regulator activity

Cellular components

• cytoplasm
• cytosol
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Protein kinase-like domain superfamily
• Pseudokinase tribbles family/serine-threonine-protein kinase 40
• Protein kinase domain
• Tribbles homologue 1, pseudokinase domain

KeywordsUniProt

• Protein kinase inhibitor

InteractionsUniProt · HPA

Protein binding partners of TRIB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• COP1
• DET1
• STK40