Seroatlas · Human Serome Atlas

CENPK

Centromere protein K

Also known as: CENP-K, CENPK_HUMAN, FKSG14, SOLT

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BS16
Gene: CENPK
Ensembl: ENSG00000123219
Chromosome: 5
Canonical length: 269 aa
Protein class: Disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

269 residues, UniProt reviewed canonical sequence.

>Q9BS16|CENPK
     1  MNQEDLDPDS TTDVGDVTNT EEELIRECEE MWKDMEECQN KLSLIGTETL TDSNAQLSLL
    61  IMQVKCLTAE LSQWQKKTPE TIPLTEDVLI TLGKEEFQKL RQDLEMVLST KESKNEKLKE
   121  DLEREQRWLD EQQQIMESLN VLHSELKNKV ETFSESRIFN ELKTKMLNIK EYKEKLLSTL
   181  GEFLEDHFPL PDRSVKKKKK NIQESSVNLI TLHEMLEILI NRLFDVPHDP YVKISDSFWP
   241  PYVELLLRNG IALRHPEDPT RIRLEAFHQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CENPK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 24 nTPM
thymus: 21 nTPM
lymph node: 14 nTPM
testis: 13 nTPM
tonsil: 12 nTPM
rectum: 11 nTPM

Single-cell type

erythrocyte progenitors: 173 nCPM
early primary spermatocytes: 165 nCPM
megakaryocyte progenitors: 163 nCPM
monocyte progenitors: 136 nCPM
neutrophil progenitors: 116 nCPM
differentiating spermatogonia: 111 nCPM

Immune cell

naive CD4 T-cell: 29 nTPM
T-reg: 23 nTPM
memory CD4 T-cell: 21 nTPM
naive CD8 T-cell: 20 nTPM
MAIT T-cell: 15 nTPM
memory CD8 T-cell: 13 nTPM

Brain region

choroid plexus: 6.5 nTPM
white matter: 6.5 nTPM
pons: 5.8 nTPM
thalamus: 5.8 nTPM
cerebellum: 5.6 nTPM
medulla oblongata: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: -1.57
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Centromere protein Cenp-K
Centromere-associated protein K

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CENPK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CENPK as an antibody target. Whether an autoantibody or antibody against CENPK could matter depends on whether native CENPK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CENPK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CENPK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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