Seroatlas · Human Serome Atlas

CENPL

Centromere protein L

Also known as: C1orf155, CENPL_HUMAN, dJ383J4.3, FLJ31044

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N0S6
Gene: CENPL
Ensembl: ENSG00000120334
Chromosome: 1
Canonical length: 344 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>Q8N0S6|CENPL
     1  MDSYSAPEST PSASSRPEDY FIGATPLQKR LESVRKQSSF ILTPPRRKIP QCSQLQEDVD
    61  PQKVAFLLHK QWTLYSLTPL YKFSYSNLKE YSRLLNAFIV AEKQKGLAVE VGEDFNIKVI
   121  FSTLLGMKGT QRDPEAFLVQ IVSKSQLPSE NREGKVLWTG WFCCVFGDSL LETVSEDFTC
   181  LPLFLANGAE SNTAIIGTWF QKTFDCYFSP LAINAFNLSW MAAMWTACKM DHYVATTEFL
   241  WSVPCSPQSL DISFAIHPED AKALWDSVHK TPGEVTQEEV DLFMDCLYSH FHRHFKIHLS
   301  ATRLVRVSTS VASAHTDGKI KILCHKYLIG VLAYLTELAI FQIE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CENPL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 9.1 nTPM

Expression across tissuesHPA

Tissue

testis: 9.1 nTPM
bone marrow: 8.9 nTPM
thymus: 8.2 nTPM
lymph node: 6 nTPM
tonsil: 5.2 nTPM
appendix: 2.9 nTPM

Single-cell type

early primary spermatocytes: 46 nCPM
monocyte progenitors: 34 nCPM
erythrocyte progenitors: 31 nCPM
breast myoepithelial cells: 21 nCPM
extravillous trophoblasts: 20 nCPM
cardiomyocytes: 20 nCPM

Immune cell

NK-cell: 8.6 nTPM
T-reg: 7.2 nTPM
naive CD8 T-cell: 6 nTPM
MAIT T-cell: 5.5 nTPM
naive CD4 T-cell: 5.5 nTPM
memory CD8 T-cell: 5.4 nTPM

Brain region

cerebral cortex: 5.8 nTPM
white matter: 5.1 nTPM
medulla oblongata: 5 nTPM
spinal cord: 4.8 nTPM
pons: 4.5 nTPM
basal ganglia: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0.07
gnomAD missense Z: 0.76
DepMap mean gene effect: -0.81
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

chromosome segregation

Cellular components

Protein domainsUniProt · Pfam · InterPro

Centromere subunit L
Centromere protein L

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CENPL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CENPL as an antibody target. Whether an autoantibody or antibody against CENPL could matter depends on whether native CENPL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CENPL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CENPL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...