Seroatlas · Human Serome Atlas

CENPI

Centromere protein I

Also known as: CENP-I, CENPI_HUMAN, FSHPRH1, LRPR1, Mis6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92674
Gene: CENPI
Ensembl: ENSG00000102384
Chromosome: X
Canonical length: 756 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

This gene encodes a centromere protein that is a component of the CENPA-NAC (nucleosome-associated) complex. This complex is critical for accurate chromosome alignment and segregation and it ensures proper mitotic progression. This protein regulates the recruitment of kinetochore-associated proteins that are required to generate the spindle checkpoint signal. The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. Mutations in this gene may be involved in human X-linked disorders of gonadal development and gametogenesis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 13. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

756 residues, UniProt reviewed canonical sequence.

>Q92674|CENPI
     1  MSPQKRVKNV QAQNRTSQGS SSFQTTLSAW KVKQDPSNSK NISKHGQNNP VGDYEHADDQ
    61  AEEDALQMAV GYFEKGPIKA SQNKDKTLEK HLKTVENVAW KNGLASEEID ILLNIALSGK
   121  FGNAVNTRIL KCMIPATVIS EDSVVKAVSW LCVGKCSGST KVLFYRWLVA MFDFIDRKEQ
   181  INLLYGFFFA SLQDDALCPY VCHLLYLLTK KENVKPFRVR KLLDLQAKMG MQPHLQALLS
   241  LYKFFAPALI SVSLPVRKKI YFKNSENLWK TALLAVKQRN RGPSPEPLKL MLGPANVRPL
   301  KRKWNSLSVI PVLNSSSYTK ECGKKEMSLS DCLNRSGSFP LEQLQSFPQL LQNIHCLELP
   361  SQMGSVLNNS LLLHYINCVR DEPVLLRFYY WLSQTLQEEC IWYKVNNYEH GKEFTNFLDT
   421  IIRAECFLQE GFYSCEAFLY KSLPLWDGLC CRSQFLQLVS WIPFSSFSEV KPLLFDHLAQ
   481  LFFTSTIYFK CSVLQSLKEL LQNWLLWLSM DIHMKPVTNS PLETTLGGSM NSVSKLIHYV
   541  GWLSTTAMRL ESNNTFLLHF ILDFYEKVCD IYINYNLPLV VLFPPGIFYS ALLSLDTSIL
   601  NQLCFIMHRY RKNLTAAKKN ELVQKTKSEF NFSSKTYQEF NHYLTSMVGC LWTSKPFGKG
   661  IYIDPEILEK TGVAEYKNSL NVVHHPSFLS YAVSFLLQES PEERTVNVSS IRGKKWSWYL
   721  DYLFSQGLQG LKLFIRSSVH HSSIPRAEGI NCNNQY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CENPI can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 5.2 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 5.2 nTPM
thymus: 4.9 nTPM
tonsil: 4.4 nTPM
lymph node: 4.1 nTPM
skin: 3.1 nTPM
rectum: 2.7 nTPM

Single-cell type

monocyte progenitors: 62 nCPM
erythrocyte progenitors: 48 nCPM
neutrophil progenitors: 34 nCPM
megakaryocyte progenitors: 32 nCPM
respiratory deuterosomal cells: 27 nCPM
enteric transient amplifying cells: 15 nCPM

Immune cell

neutrophil: 1.3 nTPM
basophil: 1.2 nTPM
T-reg: 0.9 nTPM
plasmacytoid DC: 0.8 nTPM
NK-cell: 0.7 nTPM
non-classical monocyte: 0.6 nTPM

Brain region

white matter: 15 nTPM
cerebellum: 15 nTPM
cerebral cortex: 13 nTPM
medulla oblongata: 13 nTPM
hippocampal formation: 12 nTPM
hypothalamus: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CENPI.

Disease | ImmuneIEDB

Conditions an epitope on CENPI was assayed in.

hepatocellular carcinoma T cell
berylliosis T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 1.46
DepMap mean gene effect: -0.68
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Centromere protein I
Mis6

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CENPI in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CENPI as an antibody target. Whether an autoantibody or antibody against CENPI could matter depends on whether native CENPI is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CENPI is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CENPI as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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