Seroatlas · Human Serome Atlas

CENPS

Centromere protein S

Also known as: APITD1, CENP-S, CENPS_HUMAN, FAAP16, MHF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N2Z9
Gene
CENPS
Ensembl
ENSG00000175279
Chromosome
1
Canonical length
138 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

138 residues, UniProt reviewed canonical sequence.

>Q8N2Z9|CENPS
     1  MEEEAETEEQ QRFSYQQRLK AAVHYTVGCL CEEVALDKEM QFSKQTIAAI SELTFRQCEN
    61  FAKDLEMFAR HAKRTTINTE DVKLLARRSN SLLKYITDKS EEIAQINLER KAQKKKKSED
   121  GSKNSRQPAE AGVVESEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CENPS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • testis: 46 nTPM
  • kidney: 26 nTPM
  • parathyroid gland: 14 nTPM
  • pituitary gland: 14 nTPM
  • duodenum: 12 nTPM
  • epididymis: 12 nTPM

Single-cell type

  • late primary spermatocytes: 30 nCPM
  • late spermatids: 25 nCPM
  • ependymal cells: 15 nCPM
  • early primary spermatocytes: 13 nCPM
  • early spermatids: 11 nCPM
  • choroid plexus epithelial cells: 9.9 nCPM

Immune cell

  • memory B-cell: 6.9 nTPM
  • naive B-cell: 6.1 nTPM
  • non-classical monocyte: 6.1 nTPM
  • plasmacytoid DC: 5 nTPM
  • naive CD4 T-cell: 4.5 nTPM
  • T-reg: 4.5 nTPM

Brain region

  • cerebral cortex: 6.5 nTPM
  • choroid plexus: 5.9 nTPM
  • amygdala: 3.5 nTPM
  • hypothalamus: 3.5 nTPM
  • thalamus: 3.5 nTPM
  • basal ganglia: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.71
gnomAD pLI
0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CENPS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CENPS as an antibody target. Whether an autoantibody or antibody against CENPS could matter depends on whether native CENPS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CENPS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CENPS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CENPS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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