Seroatlas · Human Serome Atlas

ATF1

Cyclic AMP-dependent transcription factor ATF-1

Also known as: ATF1_HUMAN, TREB36

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P18846
Gene
ATF1
Ensembl
ENSG00000123268
Chromosome
12
Canonical length
271 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>P18846|ATF1
     1  MEDSHKSTTS ETAPQPGSAV QGAHISHIAQ QVSSLSESEE SQDSSDSIGS SQKAHGILAR
    61  RPSYRKILKD LSSEDTRGRK GDGENSGVSA AVTSMSVPTP IYQTSSGQYI AIAPNGALQL
   121  ASPGTDGVQG LQTLTMTNSG STQQGTTILQ YAQTSDGQQI LVPSNQVVVQ TASGDMQTYQ
   181  IRTTPSATSL PQTVVMTSPV TLTSQTTKTD DPQLKREIRL MKNREAAREC RRKKKEYVKC
   241  LENRVAVLEN QNKTLIEELK TLKDLYSNKS V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 30 nTPM
  • thymus: 27 nTPM
  • ovary: 23 nTPM
  • tongue: 22 nTPM
  • thyroid gland: 21 nTPM
  • lymph node: 20 nTPM

Single-cell type

  • extravillous trophoblasts: 148 nCPM
  • syncytiotrophoblasts: 147 nCPM
  • myonuclei: 136 nCPM
  • cardiomyocytes: 126 nCPM
  • migrating cytotrophoblasts: 105 nCPM
  • salivary basal cells: 100 nCPM

Immune cell

  • eosinophil: 43 nTPM
  • T-reg: 29 nTPM
  • naive CD4 T-cell: 27 nTPM
  • memory CD8 T-cell: 24 nTPM
  • MAIT T-cell: 23 nTPM
  • memory CD4 T-cell: 22 nTPM

Brain region

  • cerebellum: 33 nTPM
  • choroid plexus: 21 nTPM
  • hypothalamus: 20 nTPM
  • white matter: 17 nTPM
  • cerebral cortex: 17 nTPM
  • midbrain: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ATF1.

Disease | AllUniProt

Conditions ATF1 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0.63
gnomAD missense Z
1.28
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATF1 as an antibody target. Whether an autoantibody or antibody against ATF1 could matter depends on whether native ATF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ATF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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