Seroatlas · Human Serome Atlas

CASP1

Caspase-1

Also known as: CASP1_HUMAN, ICE, IL1BC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P29466
Gene
CASP1
Ensembl
ENSG00000137752
Chromosome
11
Canonical length
404 aa
Protein class
Cancer-related genes, Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

404 residues, UniProt reviewed canonical sequence.

>P29466|CASP1
     1  MADKVLKEKR KLFIRSMGEG TINGLLDELL QTRVLNKEEM EKVKRENATV MDKTRALIDS
    61  VIPKGAQACQ ICITYICEED SYLAGTLGLS ADQTSGNYLN MQDSQGVLSS FPAPQAVQDN
   121  PAMPTSSGSE GNVKLCSLEE AQRIWKQKSA EIYPIMDKSS RTRLALIICN EEFDSIPRRT
   181  GAEVDITGMT MLLQNLGYSV DVKKNLTASD MTTELEAFAH RPEHKTSDST FLVFMSHGIR
   241  EGICGKKHSE QVPDILQLNA IFNMLNTKNC PSLKDKPKVI IIQACRGDSP GVVWFKDSVG
   301  VSGNLSLPTT EEFEDDAIKK AHIEKDFIAF CSSTPDNVSW RHPTMGSVFI GRLIEHMQEY
   361  ACSCDVEEIF RKVRFSFEQP DGRAQMPTTE RVTLTRCFYL FPGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CASP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
122 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 122 nTPM
  • duodenum: 121 nTPM
  • spleen: 87 nTPM
  • appendix: 58 nTPM
  • lymph node: 50 nTPM
  • rectum: 47 nTPM

Single-cell type

  • monocytes: 165 nCPM
  • hofbauer cells: 135 nCPM
  • neutrophils: 134 nCPM
  • kupffer cells: 118 nCPM
  • cdc: 113 nCPM
  • enterocytes: 95 nCPM

Immune cell

  • non-classical monocyte: 377 nTPM
  • intermediate monocyte: 355 nTPM
  • classical monocyte: 244 nTPM
  • neutrophil: 220 nTPM
  • total PBMC: 218 nTPM
  • myeloid DC: 216 nTPM

Brain region

  • white matter: 10 nTPM
  • medulla oblongata: 9.7 nTPM
  • cerebral cortex: 9.3 nTPM
  • spinal cord: 8.1 nTPM
  • pons: 7.5 nTPM
  • thalamus: 7.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
-0.06
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CASP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CASP1 as an antibody target. Whether an autoantibody or antibody against CASP1 could matter depends on whether native CASP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CASP1 is annotated at the cell surface, where native CASP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CASP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CASP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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