Seroatlas · Human Serome Atlas

GSDMD

Gasdermin-D

Also known as: DF5L, FLJ12150, GSDMD_HUMAN, GSDMDC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P57764
Gene: GSDMD
Ensembl: ENSG00000104518
Chromosome: 8
Canonical length: 484 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm
Secretome location: Intracellular and membrane
Quaternary structure: Homooligomer

OverviewNCBI Gene

Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

484 residues, UniProt reviewed canonical sequence.

>P57764|GSDMD
     1  MGSAFERVVR RVVQELDHGG EFIPVTSLQS STGFQPYCLV VRKPSSSWFW KPRYKCVNLS
    61  IKDILEPDAA EPDVQRGRSF HFYDAMDGQI QGSVELAAPG QAKIAGGAAV SDSSSTSMNV
   121  YSLSVDPNTW QTLLHERHLR QPEHKVLQQL RSRGDNVYVV TEVLQTQKEV EVTRTHKREG
   181  SGRFSLPGAT CLQGEGQGHL SQKKTVTIPS GSTLAFRVAQ LVIDSDLDVL LFPDKKQRTF
   241  QPPATGHKRS TSEGAWPQLP SGLSMMRCLH NFLTDGVPAE GAFTEDFQGL RAEVETISKE
   301  LELLDRELCQ LLLEGLEGVL RDQLALRALE EALEQGQSLG PVEPLDGPAG AVLECLVLSS
   361  GMLVPELAIP VVYLLGALTM LSETQHKLLA EALESQTLLG PLELVGSLLE QSAPWQERST
   421  MSLPPGLLGN SWGEGAPAWV LLDECGLELG EDTPHVCWEP QAQGRMCALY ASLALLSGLS
   481  QEPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSDMD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 117 nTPM

Expression across tissuesHPA

Tissue

spleen: 117 nTPM
liver: 85 nTPM
small intestine: 58 nTPM
lung: 53 nTPM
kidney: 53 nTPM
duodenum: 48 nTPM

Single-cell type

foveolar cells: 29 nCPM
papillary tip epithelial cells: 25 nCPM
proximal tubule cells: 22 nCPM
enterocytes: 22 nCPM
astrocytes: 20 nCPM
gastric chief cells: 20 nCPM

Immune cell

intermediate monocyte: 73 nTPM
T-reg: 71 nTPM
non-classical monocyte: 69 nTPM
basophil: 66 nTPM
gdT-cell: 55 nTPM
memory CD8 T-cell: 54 nTPM

Brain region

choroid plexus: 14 nTPM
medulla oblongata: 7.3 nTPM
spinal cord: 6.1 nTPM
midbrain: 6 nTPM
pons: 6 nTPM
white matter: 5.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: 0.6
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GSDMD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CASP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GSDMD as an antibody target. Whether an autoantibody or antibody against GSDMD could matter depends on whether native GSDMD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GSDMD is annotated at the cell surface, where native GSDMD is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GSDMD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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