CARD18
Caspase recruitment domain-containing protein 18
Also known as: CAR18_HUMAN, ICEBERG, pseudo-ICE, UNQ5804
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P57730
- Gene
- CARD18
- Ensembl
- ENSG00000255501
- Chromosome
- 11
- Canonical length
- 90 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Enables CARD domain binding activity and caspase binding activity. Involved in negative regulation of interleukin-1 beta production. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
90 residues, UniProt reviewed canonical sequence.
>P57730|CARD18
1 MADQLLRKKR RIFIHSVGAG TINALLDCLL EDEVISQEDM NKVRDENDTV MDKARVLIDL
61 VTGKGPKSCC KFIKHLCEED PQLASKMGLHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CARD18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.29
- Highest tissue expression
- 40 nTPM
Expression across tissuesHPA
Tissue
- skin: 40 nTPM
- breast: 7 nTPM
- vagina: 2.6 nTPM
- esophagus: 2.5 nTPM
- cervix: 1.8 nTPM
- placenta: 1.4 nTPM
Single-cell type
- cytotrophoblasts: 142 nCPM
- early primary spermatocytes: 115 nCPM
- müller glia: 114 nCPM
- gastric progenitor cells: 108 nCPM
- bergmann glia: 96 nCPM
- extravillous trophoblasts: 86 nCPM
Immune cell
- neutrophil: 0.3 nTPM
- basophil: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebral cortex: 0.8 nTPM
- cerebellum: 0.6 nTPM
- pons: 0.6 nTPM
- basal ganglia: 0.5 nTPM
- white matter: 0.5 nTPM
- amygdala: 0.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.85
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.52
- DepMap mean gene effect
- 0.11
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- inflammatory response
- negative regulation of interleukin-1 beta production
- negative regulation of protein binding
- proteolysis
- regulation of apoptotic process
Molecular functions
- CARD domain binding
- caspase binding
- cysteine-type endopeptidase activity
- cysteine-type endopeptidase inhibitor activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CARD18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CARD18 as an antibody target. Whether an autoantibody or antibody against CARD18 could matter depends on whether native CARD18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CARD18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CARD18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...