Seroatlas · Human Serome Atlas

ZNF830

Zinc finger protein 830

Also known as: CCDC16, MGC20398, OMCG1, ZN830_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96NB3
Gene
ZNF830
Ensembl
ENSG00000198783
Chromosome
17
Canonical length
372 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be involved in several processes, including mitotic DNA integrity checkpoint signaling; nuclear DNA replication; and preantral ovarian follicle growth. Predicted to act upstream of or within several processes, including blastocyst growth; chromosome organization; and intestinal epithelial structure maintenance. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

372 residues, UniProt reviewed canonical sequence.

>Q96NB3|ZNF830
     1  MASSASARTP AGKRVINQEE LRRLMKEKQR LSTSRKRIES PFAKYNRLGQ LSCALCNTPV
    61  KSELLWQTHV LGKQHREKVA ELKGAKEASQ GSSASSAPHS VKRKAPDADD QDVKRAKATL
   121  VPQVQPSTSA WTTNFDKIGK EFIRATPSKP SGLSLLPDYE DEEEEEEEEE GDGERKRGDA
   181  SKPLSDAQGK EHSVSSSREV TSSVLPNDFF STNPPKAPII PHSGSIEKAE IHEKVVERRE
   241  NTAEALPEGF FDDPEVDARV RKVDAPKDQM DKEWDEFQKA MRQVNTISEA IVAEEDEEGR
   301  LDRQIGEIDE QIECYRRVEK LRNRQDEIKN KLKEILTIKE LQKKEEENAD SDDEGELQDL
   361  LSQDWRVKGA LL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF830 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 14 nTPM
  • lymph node: 13 nTPM
  • thymus: 13 nTPM
  • ovary: 12 nTPM
  • tonsil: 11 nTPM
  • bone marrow: 11 nTPM

Single-cell type

  • differentiating spermatogonia: 49 nCPM
  • early primary spermatocytes: 43 nCPM
  • fallopian secretory cells: 38 nCPM
  • undifferentiated spermatogonia: 35 nCPM
  • mast cells: 35 nCPM
  • ovarian stromal cells: 35 nCPM

Immune cell

  • eosinophil: 41 nTPM
  • basophil: 31 nTPM
  • naive CD4 T-cell: 26 nTPM
  • naive CD8 T-cell: 21 nTPM
  • memory CD8 T-cell: 18 nTPM
  • memory CD4 T-cell: 17 nTPM

Brain region

  • cerebellum: 12 nTPM
  • white matter: 10 nTPM
  • cerebral cortex: 8.3 nTPM
  • choroid plexus: 8.2 nTPM
  • basal ganglia: 8 nTPM
  • hypothalamus: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0.06
gnomAD missense Z
0.4
DepMap mean gene effect
-0.96
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF830 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF830 as an antibody target. Whether an autoantibody or antibody against ZNF830 could matter depends on whether native ZNF830 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF830 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF830 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF830. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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