Seroatlas · Human Serome Atlas

ATAT1

Alpha-tubulin N-acetyltransferase 1

Also known as: ATAT_HUMAN, C6orf134, Em:AB023049.7, FLJ13158, MEC17

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5SQI0
Gene
ATAT1
Ensembl
ENSG00000137343
Chromosome
6
Canonical length
421 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a protein that localizes to clathrin-coated pits, where it acetylates alpha tubulin on lysine 40. This process may be important in microtubule growth, for instance during chemotaxis and the formation of cilium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

421 residues, UniProt reviewed canonical sequence.

>Q5SQI0|ATAT1
     1  MEFPFDVDAL FPERITVLDQ HLRPPARRPG TTTPARVDLQ QQIMTIIDEL GKASAKAQNL
    61  SAPITSASRM QSNRHVVYIL KDSSARPAGK GAIIGFIKVG YKKLFVLDDR EAHNEVEPLC
   121  ILDFYIHESV QRHGHGRELF QYMLQKERVE PHQLAIDRPS QKLLKFLNKH YNLETTVPQV
   181  NNFVIFEGFF AHQHRPPAPS LRATRHSRAA AVDPTPAAPA RKLPPKRAEG DIKPYSSSDR
   241  EFLKVAVEPP WPLNRAPRRA TPPAHPPPRS SSLGNSPERG PLRPFVPEQE LLRSLRLCPP
   301  HPTARLLLAA DPGGSPAQRR RTRGTPPGLV AQSCCYSRHG GVNSSSPNTG NQDSKQGEQE
   361  TKNRSASEEQ ALSQDGSGEK PMHTAPPQAP APPAQSWTVG GDILNARFIR NLQERRSTRP
   421  W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATAT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 31 nTPM
  • cerebral cortex: 31 nTPM
  • hippocampal formation: 30 nTPM
  • hypothalamus: 30 nTPM
  • basal ganglia: 28 nTPM
  • spinal cord: 27 nTPM

Single-cell type

  • early spermatids: 48 nCPM
  • late spermatids: 42 nCPM
  • oligodendrocyte progenitor cells: 28 nCPM
  • ependymal cells: 26 nCPM
  • astrocytes: 24 nCPM
  • bergmann glia: 22 nCPM

Immune cell

  • basophil: 0.5 nTPM
  • memory B-cell: 0.5 nTPM
  • plasmacytoid DC: 0.5 nTPM
  • classical monocyte: 0.4 nTPM
  • myeloid DC: 0.4 nTPM
  • naive CD4 T-cell: 0.4 nTPM

Brain region

  • cerebral cortex: 6.8 nTPM
  • hypothalamus: 6.8 nTPM
  • basal ganglia: 5.4 nTPM
  • white matter: 5.4 nTPM
  • midbrain: 5.3 nTPM
  • thalamus: 4.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0
gnomAD missense Z
1.38
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Gcn5-related N-acetyltransferase (GNAT) domain, ATAT-type
  • Alpha-tubulin N-acetyltransferase
  • GNAT acetyltransferase, Mec-17

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATAT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATAT1 as an antibody target. Whether an autoantibody or antibody against ATAT1 could matter depends on whether native ATAT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATAT1 is annotated at the cell surface, where native ATAT1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ATAT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ATAT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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