F-box/LRR-repeat protein 15, leucine rich repeat domain
PF25372
Definition
This domain represents a set of tandem leucine rich repeats found in human F-box/LRR-repeat protein 15 (FBXL15) and similar eukaryotic proteins. FBXL15 is the substrate recognition component of a SCF (SKP1-CUL1-F-box protein), an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signalling pathway. It is required for dorsal/ventral pattern formation and bone mass maintenance PMID:21572392.
11 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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