FBXL2

Protein identityUniProt · HPA

UniProt accession

Q9UKC9

Gene

FBXL2

Ensembl

ENSG00000153558

Chromosome

3

Canonical length

423 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli,Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

423 residues, UniProt reviewed canonical sequence.

>Q9UKC9|FBXL2
     1  MVFSNNDEGL INKKLPKELL LRIFSFLDIV TLCRCAQISK AWNILALDGS NWQRIDLFNF
    61  QTDVEGRVVE NISKRCGGFL RKLSLRGCIG VGDSSLKTFA QNCRNIEHLN LNGCTKITDS
   121  TCYSLSRFCS KLKHLDLTSC VSITNSSLKG ISEGCRNLEY LNLSWCDQIT KDGIEALVRG
   181  CRGLKALLLR GCTQLEDEAL KHIQNYCHEL VSLNLQSCSR ITDEGVVQIC RGCHRLQALC
   241  LSGCSNLTDA SLTALGLNCP RLQILEAARC SHLTDAGFTL LARNCHELEK MDLEECILIT
   301  DSTLIQLSIH CPKLQALSLS HCELITDDGI LHLSNSTCGH ERLRVLELDN CLLITDVALE
   361  HLENCRGLER LELYDCQQVT RAGIKRMRAQ LPHVKVHAYF APVTPPTAVA GSGQRLCRCC
   421  VIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

5.8 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.52

gnomAD pLI

0.01

gnomAD missense Z

2.46

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• host-mediated perturbation of viral RNA genome replication
• negative regulation of NLRP3 inflammasome complex assembly
• protein modification process
• protein monoubiquitination
• protein ubiquitination
• proteolysis
• regulation of autophagy
• regulation of inflammatory response
• regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Molecular functions

• calmodulin binding
• phosphatidylinositol 3-kinase regulatory subunit binding
• protein phosphatase binding
• ubiquitin-like ligase-substrate adaptor activity

Cellular components

• cytoplasm
• membrane
• SCF ubiquitin ligase complex

Protein domainsUniProt · Pfam · InterPro

• F-box domain
• Leucine-rich repeat, cysteine-containing subtype
• Leucine-rich repeat domain superfamily
• F-box/Leucine-rich repeat
• F-box/LRR-repeat protein 15-like, leucin rich repeat domain
• F-box-like
• F-box/LRR-repeat protein 15, leucine rich repeat domain

KeywordsUniProt

• Calcium
• Calmodulin-binding
• Host-virus interaction
• Isopeptide bond
• Leucine-rich repeat
• Lipoprotein
• Membrane
• Phosphoprotein
• Prenylation
• Repeat
• Ubl conjugation
• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of FBXL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PTPN13
• PIK3R2
• SKP1