Seroatlas · Human Serome Atlas

FBXL15

F-box/LRR-repeat protein 15

Also known as: Fbl15, FBXO37, FXL15_HUMAN, MGC11279

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H469
Gene: FBXL15
Ensembl: ENSG00000107872
Chromosome: 10
Canonical length: 300 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Involved in several processes, including G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of BMP signaling pathway. Located in cytoplasm. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

300 residues, UniProt reviewed canonical sequence.

>Q9H469|FBXL15
     1  MEPPMEPSGG EQEPGAVRFL DLPWEDVLLP HVLNRVPLRQ LLRLQRVSRA FRSLVQLHLA
    61  GLRRFDAAQV GPQIPRAALA RLLRDAEGLQ ELALAPCHEW LSDEDLVPVL ARNPQLRSVA
   121  LGGCGQLSRR ALGALAEGCP RLQRLSLAHC DWVDGLALRG LADRCPALEE LDLTACRQLK
   181  DEAIVYLAQR RGAGLRSLSL AVNANVGDAA VQELARNCPE LHHLDLTGCL RVGSDGVRTL
   241  AEYCPVLRSL RVRHCHHVAE SSLSRLRKRG VDIDVEPPLH QALVLLQDMA GFAPFVNLQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXL15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 60 nTPM
pituitary gland: 54 nTPM
basal ganglia: 50 nTPM
amygdala: 46 nTPM
hippocampal formation: 43 nTPM
cerebellum: 42 nTPM

Single-cell type

enterocytes: 157 nCPM
parietal cells: 106 nCPM
epididymal clear cells: 78 nCPM
hepatic stellate cells: 78 nCPM
colonocytes: 77 nCPM
esophageal suprabasal cells: 75 nCPM

Immune cell

eosinophil: 72 nTPM
classical monocyte: 63 nTPM
myeloid DC: 60 nTPM
non-classical monocyte: 57 nTPM
plasmacytoid DC: 53 nTPM
basophil: 52 nTPM

Brain region

cerebral cortex: 53 nTPM
medulla oblongata: 43 nTPM
pons: 40 nTPM
hippocampal formation: 36 nTPM
thalamus: 36 nTPM
hypothalamus: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0.01
gnomAD missense Z: 1.67
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXL15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXL15 as an antibody target. Whether an autoantibody or antibody against FBXL15 could matter depends on whether native FBXL15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXL15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXL15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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