ADAM-TS Spacer 1

Definition

This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins PMID:11279086. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organisation among its members [[cite:PMID:8995297],[cite:PMID:10464288]]. Members of the ADAM-TS family have been implicated in a range of diseases [[cite:PMID:29885460],[cite:PMID:34268335]]. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles PMID:29885460. Examples of ADAM-TS-like proteins are papilin PMID:11076767 and punctin PMID:11805097.

25 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (25 proteins: gene, accession, name)

• ADAMTS1
• ADAMTS10
• ADAMTS12
• ADAMTS13
• ADAMTS14
• ADAMTS15
• ADAMTS16
• ADAMTS17
• ADAMTS18
• ADAMTS19
• ADAMTS2
• ADAMTS20
• ADAMTS3
• ADAMTS4
• ADAMTS5
• ADAMTS6
• ADAMTS7
• ADAMTS8
• ADAMTS9
• ADAMTSL1
• ADAMTSL2
• ADAMTSL4
• ADAMTSL5
• PAPLN
• THSD4