ADAMTSL5

Protein identityUniProt · HPA

UniProt accession

Q6ZMM2

Gene

ADAMTSL5

Canonical length

481 aa

Protein class

Predicted intracellular proteins, Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for ADAMTSL5 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

481 residues, UniProt reviewed canonical sequence.

>Q6ZMM2|ADAMTSL5
     1  MGKLRPGRVE WLASGHTERP HLFQNLLLFL WALLNCGLGV SAQGPGEWTP WVSWTRCSSS
    61  CGRGVSVRSR RCLRLPGEEP CWGDSHEYRL CQLPDCPPGA VPFRDLQCAL YNGRPVLGTQ
   121  KTYQWVPFHG APNQCDLNCL AEGHAFYHSF GRVLDGTACS PGAQGVCVAG RCLSAGCDGL
   181  LGSGALEDRC GRCGGANDSC LFVQRVFRDA GAFAGYWNVT LIPEGARHIR VEHRSRNHLA
   241  LMGGDGRYVL NGHWVVSPPG TYEAAGTHVV YTRDTGPQET LQAAGPTSHD LLLQVLLQEP
   301  NPGIEFEFWL PRERYSPFQA RVQALGWPLR QPQPRGVEPQ PPAAPAVTPA QTPTLAPDPC
   361  PPCPDTRGRA HRLLHYCGSD FVFQARVLGH HHQAQETRYE VRIQLVYKNR SPLRAREYVW
   421  APGHCPCPML APHRDYLMAV QRLVSPDGTQ DQLLLPHAGY ARPWSPAEDS RIRLTARRCP
   481  G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADAMTSL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

31 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ADAMTSL5.

Disease | ImmuneIEDB

Conditions an epitope on ADAMTSL5 was assayed in.

• psoriasis T cell

ReferencesPubMed · IEDB

Publications for ADAMTSL5 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.15

gnomAD pLI

0

gnomAD missense Z

-0.45

DepMap mean gene effect

-0.19

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• extracellular matrix organization

Molecular functions

• heparin binding
• microfibril binding

Cellular components

• extracellular matrix
• extracellular region
• microfibril

Protein domainsUniProt · Pfam · InterPro

• Thrombospondin type-1 (TSP1) repeat
• Netrin domain
• Tissue inhibitor of metalloproteinases-like, OB-fold
• ADAMTS/ADAMTS-like, Spacer 1
• ADAMTS/ADAMTS-like
• Netrin module, non-TIMP type
• Thrombospondin type-1 repeat superfamily
• ADAMTS/ADAMTS-like, cysteine-rich domain 3
• ADAMTS and ADAMTS-like
• Thrombospondin type 1 domain
• UNC-6/NTR/C345C module
• ADAM-TS Spacer 1
• ADAMTS cysteine-rich domain

KeywordsUniProt

• Disulfide bond
• Extracellular matrix
• Glycoprotein
• Heparin-binding
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of ADAMTSL5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FBN1
• FBN2