Seroatlas · Human Serome Atlas

ADAMTSL1

ADAMTS-like protein 1

Also known as: ADAMTSR1, ATL1_HUMAN, C9orf94, FLJ35283

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6G6
Gene: ADAMTSL1
Ensembl: ENSG00000178031
Chromosome: 9
Canonical length: 1762 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene encodes a secreted protein and member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1762 residues, UniProt reviewed canonical sequence.

>Q8N6G6|ADAMTSL1
     1  MECCRRATPG TLLLFLAFLL LSSRTARSEE DRDGLWDAWG PWSECSRTCG GGASYSLRRC
    61  LSSKSCEGRN IRYRTCSNVD CPPEAGDFRA QQCSAHNDVK HHGQFYEWLP VSNDPDNPCS
   121  LKCQAKGTTL VVELAPKVLD GTRCYTESLD MCISGLCQIV GCDHQLGSTV KEDNCGVCNG
   181  DGSTCRLVRG QYKSQLSATK SDDTVVAIPY GSRHIRLVLK GPDHLYLETK TLQGTKGENS
   241  LSSTGTFLVD NSSVDFQKFP DKEILRMAGP LTADFIVKIR NSGSADSTVQ FIFYQPIIHR
   301  WRETDFFPCS ATCGGGYQLT SAECYDLRSN RVVADQYCHY YPENIKPKPK LQECNLDPCP
   361  ASDGYKQIMP YDLYHPLPRW EATPWTACSS SCGGGIQSRA VSCVEEDIQG HVTSVEEWKC
   421  MYTPKMPIAQ PCNIFDCPKW LAQEWSPCTV TCGQGLRYRV VLCIDHRGMH TGGCSPKTKP
   481  HIKEECIVPT PCYKPKEKLP VEAKLPWFKQ AQELEEGAAV SEEPSFIPEA WSACTVTCGV
   541  GTQVRIVRCQ VLLSFSQSVA DLPIDECEGP KPASQRACYA GPCSGEIPEF NPDETDGLFG
   601  GLQDFDELYD WEYEGFTKCS ESCGGGVQEA VVSCLNKQTR EPAEENLCVT SRRPPQLLKS
   661  CNLDPCPARW EIGKWSPCSL TCGVGLQTRD VFCSHLLSRE MNETVILADE LCRQPKPSTV
   721  QACNRFNCPP AWYPAQWQPC SRTCGGGVQK REVLCKQRMA DGSFLELPET FCSASKPACQ
   781  QACKKDDCPS EWLLSDWTEC STSCGEGTQT RSAICRKMLK TGLSTVVNST LCPPLPFSSS
   841  IRPCMLATCA RPGRPSTKHS PHIAAARKVY IQTRRQRKLH FVVGGFAYLL PKTAVVLRCP
   901  ARRVRKPLIT WEKDGQHLIS STHVTVAPFG YLKIHRLKPS DAGVYTCSAG PAREHFVIKL
   961  IGGNRKLVAR PLSPRSEEEV LAGRKGGPKE ALQTHKHQNG IFSNGSKAEK RGLAANPGSR
  1021  YDDLVSRLLE QGGWPGELLA SWEAQDSAER NTTSEEDPGA EQVLLHLPFT MVTEQRRLDD
  1081  ILGNLSQQPE ELRDLYSKHL VAQLAQEIFR SHLEHQDTLL KPSERRTSPV TLSPHKHVSG
  1141  FSSSLRTSST GDAGGGSRRP HRKPTILRKI SAAQQLSASE VVTHLGQTVA LASGTLSVLL
  1201  HCEAIGHPRP TISWARNGEE VQFSDRILLQ PDDSLQILAP VEADVGFYTC NATNALGYDS
  1261  VSIAVTLAGK PLVKTSRMTV INTEKPAVTV DIGSTIKTVQ GVNVTINCQV AGVPEAEVTW
  1321  FRNKSKLGSP HHLHEGSLLL TNVSSSDQGL YSCRAANLHG ELTESTQLLI LDPPQVPTQL
  1381  EDIRALLAAT GPNLPSVLTS PLGTQLVLDP GNSALLGCPI KGHPVPNITW FHGGQPIVTA
  1441  TGLTHHILAA GQILQVANLS GGSQGEFSCL AQNEAGVLMQ KASLVIQDYW WSVDRLATCS
  1501  ASCGNRGVQQ PRLRCLLNST EVNPAHCAGK VRPAVQPIAC NRRDCPSRWM VTSWSACTRS
  1561  CGGGVQTRRV TCQKLKASGI STPVSNDMCT QVAKRPVDTQ ACNQQLCVEW AFSSWGQCNG
  1621  PCIGPHLAVQ HRQVFCQTRD GITLPSEQCS ALPRPVSTQN CWSEACSVHW RVSLWTLCTA
  1681  TCGNYGFQSR RVECVHARTN KAVPEHLCSW GPRPANWQRC NITPCENMEC RDTTRYCEKV
  1741  KQLKLCQLSQ FKSRCCGTCG KA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADAMTSL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

endometrium: 13 nTPM
smooth muscle: 10 nTPM
prostate: 7.7 nTPM
blood vessel: 7.4 nTPM
fallopian tube: 6.3 nTPM
adrenal gland: 5.2 nTPM

Single-cell type

bergmann glia: 3,895 nCPM
colonocytes: 664 nCPM
leydig cells: 520 nCPM
renal collecting duct intercalated cells: 477 nCPM
enteric transient amplifying cells: 402 nCPM
enteric stem cells: 343 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 23 nTPM
cerebral cortex: 10 nTPM
midbrain: 8.4 nTPM
medulla oblongata: 6.9 nTPM
cerebellum: 5.9 nTPM
hypothalamus: 5.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0
gnomAD missense Z: -0.97
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADAMTSL1 as an antibody target. Whether an autoantibody or antibody against ADAMTSL1 could matter depends on whether native ADAMTSL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADAMTSL1 is annotated as secreted, so native ADAMTSL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ADAMTSL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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