IBR domain, a half RING-finger domain
PF01485
Definition
The IBR (In Between Ring fingers) domain is often found to occur between pairs of ring fingers ([pfam:PF00097]). This domain has also been called the C6HC domain and DRIL (for double RING finger linked) domain PMID:10422847. Proteins that contain two Ring fingers and an IBR domain (these proteins are also termed RBR family proteins) are thought to exist in all eukaryotic organisms. RBR family members play roles in protein quality control and can indirectly regulate transcription PMID:15152079. Evidence suggests that RBR proteins are often parts of cullin-containing ubiquitin ligase complexes. The ubiquitin ligase Parkin is an RBR family protein whose mutations are involved in forms of familial Parkinson's disease PMID:15152079PMID:12446796.
10 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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