Seroatlas · Human Serome Atlas

ANKIB1

Ankyrin repeat and IBR domain-containing protein 1

Also known as: AKIB1_HUMAN, DKFZP434A0225, KIAA1386

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2G1
Gene: ANKIB1
Ensembl: ENSG00000001629
Chromosome: 7
Canonical length: 1089 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1089 residues, UniProt reviewed canonical sequence.

>Q9P2G1|ANKIB1
     1  MGNTTTKFRK ALINGDENLA CQIYENNPQL KESLDPNTSY GEPYQHNTPL HYAARHGMNK
    61  ILGTFLGRDG NPNKRNVHNE TSMHLLCMGP QIMISEGALH PRLARPTEDD FRRADCLQMI
   121  LKWKGAKLDQ GEYERAAIDA VDNKKNTPLH YAAASGMKAC VELLVKHGGD LFAENENKDT
   181  PCDCAEKQHH KDLALNLESQ MVFSRDPEAE EIEAEYAALD KREPYEGLRP QDLRRLKDML
   241  IVETADMLQA PLFTAEALLR AHDWDREKLL EAWMSNPENC CQRSGVQMPT PPPSGYNAWD
   301  TLPSPRTPRT TRSSVTSPDE ISLSPGDLDT SLCDICMCSI SVFEDPVDMP CGHDFCRGCW
   361  ESFLNLKIQE GEAHNIFCPA YDCFQLVPVD IIESVVSKEM DKRYLQFDIK AFVENNPAIK
   421  WCPTPGCDRA VRLTKQGSNT SGSDTLSFPL LRAPAVDCGK GHLFCWECLG EAHEPCDCQT
   481  WKNWLQKITE MKPEELVGVS EAYEDAANCL WLLTNSKPCA NCKSPIQKNE GCNHMQCAKC
   541  KYDFCWICLE EWKKHSSSTG GYYRCTRYEV IQHVEEQSKE MTVEAEKKHK RFQELDRFMH
   601  YYTRFKNHEH SYQLEQRLLK TAKEKMEQLS RALKETEGGC PDTTFIEDAV HVLLKTRRIL
   661  KCSYPYGFFL EPKSTKKEIF ELMQTDLEMV TEDLAQKVNR PYLRTPRHKI IKAACLVQQK
   721  RQEFLASVAR GVAPADSPEA PRRSFAGGTW DWEYLGFASP EEYAEFQYRR RHRQRRRGDV
   781  HSLLSNPPDP DEPSESTLDI PEGGSSSRRP GTSVVSSASM SVLHSSSLRD YTPASRSENQ
   841  DSLQALSSLD EDDPNILLAI QLSLQESGLA LDEETRDFLS NEASLGAIGT SLPSRLDSVP
   901  RNTDSPRAAL SSSELLELGD SLMRLGAEND PFSTDTLSSH PLSEARSDFC PSSSDPDSAG
   961  QDPNINDNLL GNIMAWFHDM NPQSIALIPP ATTEISADSQ LPCIKDGSEG VKDVELVLPE
  1021  DSMFEDASVS EGRGTQIEEN PLEENILAGE AASQAGDSGN EAANRGDGSD VSSQTPQTSS
  1081  DWLEQVHLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKIB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

kidney: 24 nTPM
parathyroid gland: 23 nTPM
midbrain: 19 nTPM
testis: 19 nTPM
cerebral cortex: 19 nTPM
spinal cord: 18 nTPM

Single-cell type

oligodendrocytes: 684 nCPM
sertoli cells: 470 nCPM
proximal tubule cells: 316 nCPM
other brain neurons: 300 nCPM
thyrotrophs: 295 nCPM
brain inhibitory neurons: 260 nCPM

Immune cell

naive B-cell: 2 nTPM
T-reg: 1.9 nTPM
memory B-cell: 1.7 nTPM
plasmacytoid DC: 1.6 nTPM
basophil: 1.4 nTPM
memory CD8 T-cell: 1.3 nTPM

Brain region

white matter: 266 nTPM
basal ganglia: 205 nTPM
hypothalamus: 202 nTPM
cerebral cortex: 179 nTPM
thalamus: 165 nTPM
pons: 160 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.21
gnomAD pLI: 1
gnomAD missense Z: 3.16
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, RING-type
Ankyrin repeat
IBR domain
Ubiquitin interacting motif
Zinc finger, RING/FYVE/PHD-type
E3 ubiquitin ligase RBR family
Ankyrin repeat-containing domain superfamily
TRIAD supradomain
Ariadne domain
Ankyrin repeat
IBR domain, a half RING-finger domain
Ankyrin repeats (3 copies)
Ariadne domain
IBR domain
Ankyrin repeat and IBR domain-containing protein 1, RING finger, HC subclass
Ankyrin repeat and IBR domain-containing protein 1, Rcat domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKIB1 as an antibody target. Whether an autoantibody or antibody against ANKIB1 could matter depends on whether native ANKIB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKIB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKIB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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