Aldehyde dehydrogenase family
PF00171
Definition
This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases [swissprot:P00352] [ec:1.2.1.3]. Succinate-semialdehyde dehydrogenase [swissprot:P25526] [ec:1.2.1.16]. Lactaldehyde dehydrogenase [swissprot:P25553] [ec:1.2.1.22]. Benzaldehyde dehydrogenase [swissprot:P43503] [ec:1.2.1.28]. Methylmalonate-semialdehyde dehydrogenase [swissprot:Q02252] [ec:1.2.1.27]. Glyceraldehyde-3-phosphate dehydrogenase [swissprot:P81406] [ec:1.2.1.9]. Delta-1-pyrroline-5-carboxylate dehydrogenase [swissprot:P30038] EC: 1.5.1.12. Acetaldehyde dehydrogenase [swissprot:P17547] [ec:1.2.1.10]. Glutamate-5-semialdehyde dehydrogenase [swissprot:P07004] [ec:1.2.1.41]. This family also includes omega crystallin [swissprot:P30842] an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.
19 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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