ALDH3A1

Protein identityUniProt · HPA

UniProt accession

P30838

Gene

ALDH3A1

Ensembl

ENSG00000108602

Chromosome

17

Canonical length

453 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Vesicles,Plasma membrane,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>P30838|ALDH3A1
     1  MSKISEAVKR ARAAFSSGRT RPLQFRIQQL EALQRLIQEQ EQELVGALAA DLHKNEWNAY
    61  YEEVVYVLEE IEYMIQKLPE WAADEPVEKT PQTQQDELYI HSEPLGVVLV IGTWNYPFNL
   121  TIQPMVGAIA AGNSVVLKPS ELSENMASLL ATIIPQYLDK DLYPVINGGV PETTELLKER
   181  FDHILYTGST GVGKIIMTAA AKHLTPVTLE LGGKSPCYVD KNCDLDVACR RIAWGKFMNS
   241  GQTCVAPDYI LCDPSIQNQI VEKLKKSLKE FYGEDAKKSR DYGRIISARH FQRVMGLIEG
   301  QKVAYGGTGD AATRYIAPTI LTDVDPQSPV MQEEIFGPVL PIVCVRSLEE AIQFINQREK
   361  PLALYMFSSN DKVIKKMIAE TSSGGVAAND VIVHITLHSL PFGGVGNSGM GSYHGKKSFE
   421  TFSHRRSCLV RPLMNDEGLK VRYPPSPAKM TQH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ALDH3A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.23

Highest tissue expression

504 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ALDH3A1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 57 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Keratoconus

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.53

gnomAD pLI

0

gnomAD missense Z

0.3

DepMap mean gene effect

0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• aldehyde metabolic process
• lipid metabolic process
• xenobiotic metabolic process

Molecular functions

• 3-chloroallyl aldehyde dehydrogenase activity
• alcohol dehydrogenase (NADP+) activity
• aldehyde dehydrogenase (NAD+) activity
• aldehyde dehydrogenase [NAD(P)+] activity
• benzaldehyde dehydrogenase (NAD+) activity

Cellular components

• cytoplasm
• cytosol
• endoplasmic reticulum
• extracellular space
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Aldehyde dehydrogenase NAD(P)-dependent
• Aldehyde dehydrogenase domain
• Aldehyde dehydrogenase, cysteine active site
• Aldehyde/histidinol dehydrogenase
• Aldehyde dehydrogenase, N-terminal
• Aldehyde dehydrogenase, C-terminal
• Aldehyde dehydrogenase, glutamic acid active site
• Aldehyde dehydrogenase family

KeywordsUniProt

• Acetylation
• Cytoplasm
• Lipid metabolism
• NAD
• NADP
• Oxidoreductase

InteractionsUniProt · HPA

Protein binding partners of ALDH3A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CASP14