Seroatlas · Human Serome Atlas

ALDH3A2

Aldehyde dehydrogenase family 3 member A2

Also known as: AL3A2_HUMAN, ALDH10, FALDH, SLS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51648
Gene
ALDH3A2
Ensembl
ENSG00000072210
Chromosome
17
Canonical length
485 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

485 residues, UniProt reviewed canonical sequence.

>P51648|ALDH3A2
     1  MELEVRRVRQ AFLSGRSRPL RFRLQQLEAL RRMVQEREKD ILTAIAADLC KSEFNVYSQE
    61  VITVLGEIDF MLENLPEWVT AKPVKKNVLT MLDEAYIQPQ PLGVVLIIGA WNYPFVLTIQ
   121  PLIGAIAAGN AVIIKPSELS ENTAKILAKL LPQYLDQDLY IVINGGVEET TELLKQRFDH
   181  IFYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDKDC DLDIVCRRIT WGKYMNCGQT
   241  CIAPDYILCE ASLQNQIVWK IKETVKEFYG ENIKESPDYE RIINLRHFKR ILSLLEGQKI
   301  AFGGETDEAT RYIAPTVLTD VDPKTKVMQE EIFGPILPIV PVKNVDEAIN FINEREKPLA
   361  LYVFSHNHKL IKRMIDETSS GGVTGNDVIM HFTLNSFPFG GVGSSGMGAY HGKHSFDTFS
   421  HQRPCLLKSL KREGANKLRY PPNSQSKVDW GKFFLLKRFN KEKLGLLLLT FLGIVAAVLV
   481  KAEYY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ALDH3A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
269 nTPM

Expression across tissuesHPA

Tissue

  • liver: 269 nTPM
  • skin: 196 nTPM
  • adrenal gland: 191 nTPM
  • kidney: 161 nTPM
  • esophagus: 124 nTPM
  • choroid plexus: 105 nTPM

Single-cell type

  • esophageal apical cells: 341 nCPM
  • alveolar cells type 1: 297 nCPM
  • adrenal cortex cells: 278 nCPM
  • esophageal suprabasal cells: 252 nCPM
  • esophageal basal cells: 250 nCPM
  • hepatocytes: 238 nCPM

Immune cell

  • classical monocyte: 21 nTPM
  • non-classical monocyte: 21 nTPM
  • myeloid DC: 21 nTPM
  • intermediate monocyte: 18 nTPM
  • eosinophil: 18 nTPM
  • NK-cell: 15 nTPM

Brain region

  • choroid plexus: 137 nTPM
  • white matter: 54 nTPM
  • basal ganglia: 53 nTPM
  • hippocampal formation: 46 nTPM
  • hypothalamus: 45 nTPM
  • cerebral cortex: 43 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ALDH3A2.

Disease | AllUniProt

Conditions ALDH3A2 is implicated in, by any mechanism.

Disease | GeneticClinVar

182 pathogenic / likely-pathogenic of 714 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0
gnomAD missense Z
0.68
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ALDH3A2 as an antibody target. Whether an autoantibody or antibody against ALDH3A2 could matter depends on whether native ALDH3A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ALDH3A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ALDH3A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ALDH3A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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