ALDH1L2

Protein identityUniProt · HPA

UniProt accession

Q3SY69

Gene

ALDH1L2

Ensembl

ENSG00000136010

Chromosome

12

Canonical length

923 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

923 residues, UniProt reviewed canonical sequence.

>Q3SY69|ALDH1L2
     1  MLRRGSQALR RFSTGRVYFK NKLKLALIGQ SLFGQEVYSH LRKEGHRVVG VFTVPDKDGK
    61  ADPLALAAEK DGTPVFKLPK WRVKGKTIKE VAEAYRSVGA ELNVLPFCTQ FIPMDIIDSP
   121  KHGSIIYHPS ILPRHRGASA INWTLIMGDK KAGFSVFWAD DGLDTGPILL QRSCDVEPND
   181  TVDALYNRFL FPEGIKAMVE AVQLIADGKA PRIPQPEEGA TYEGIQKKEN AEISWDQSAE
   241  VLHNWIRGHD KVPGAWTEIN GQMVTFYGST LLNSSVPPGE PLEIKGAKKP GLVTKNGLVL
   301  FGNDGKALTV RNLQFEDGKM IPASQYFSTG ETSVVELTAE EVKVAETIKV IWAGILSNVP
   361  IIEDSTDFFK SGASSMDVAR LVEEIRQKCG GLQLQNEDVY MATKFEGFIQ KVVRKLRGED
   421  QEVELVVDYI SKEVNEIMVK MPYQCFINGQ FTDADDGKTY DTINPTDGST ICKVSYASLA
   481  DVDKAVAAAK DAFENGEWGR MNARERGRLM YRLADLLEEN QEELATIEAL DSGAVYTLAL
   541  KTHIGMSVQT FRYFAGWCDK IQGSTIPINQ ARPNRNLTFT KKEPLGVCAI IIPWNYPLMM
   601  LAWKSAACLA AGNTLVLKPA QVTPLTALKF AELSVKAGFP KGVINIIPGS GGIAGQRLSE
   661  HPDIRKLGFT GSTPIGKQIM KSCAVSNLKK VSLELGGKSP LIIFNDCELD KAVRMGMGAV
   721  FFNKGENCIA AGRLFVEESI HDEFVTRVVE EIKKMKIGDP LDRSTDHGPQ NHKAHLEKLL
   781  QYCETGVKEG ATLVYGGRQV QRPGFFMEPT VFTDVEDYMY LAKEESFGPI MVISKFQNGD
   841  IDGVLQRANS TEYGLASGVF TRDINKAMYV SEKLEAGTVF INTYNKTDVA APFGGVKQSG
   901  FGKDLGEEAL NEYLKTKTVT LEY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ALDH1L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.24

Highest tissue expression

38 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.92

gnomAD pLI

0

gnomAD missense Z

1.37

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• 10-formyltetrahydrofolate catabolic process
• fatty acid beta-oxidation
• folic acid metabolic process
• NADPH regeneration
• one-carbon metabolic process

Molecular functions

• aldehyde dehydrogenase (NAD+) activity
• formyltetrahydrofolate dehydrogenase activity

Cellular components

• extracellular exosome
• mitochondrial matrix
• mitochondrion
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Phosphoribosylglycinamide formyltransferase, active site
• Formyl transferase, N-terminal
• Formyl transferase, C-terminal
• Phosphopantetheine attachment site
• Phosphopantetheine binding ACP domain
• Formyl transferase-like, C-terminal domain superfamily
• 10-formyltetrahydrofolate dehydrogenase
• Aldehyde dehydrogenase domain
• Aldehyde dehydrogenase, cysteine active site
• Aldehyde/histidinol dehydrogenase
• Aldehyde dehydrogenase, N-terminal
• Aldehyde dehydrogenase, C-terminal
• Aldehyde dehydrogenase, glutamic acid active site
• Formyl transferase, N-terminal domain superfamily
• ACP-like superfamily
• Formyl transferase, C-terminal domain superfamily
• Aldehyde dehydrogenase family
• Phosphopantetheine attachment site
• Formyl transferase
• Formyl transferase, C-terminal domain

KeywordsUniProt

• Acetylation
• Mitochondrion
• NADP
• One-carbon metabolism
• Oxidoreductase
• Phosphopantetheine
• Phosphoprotein
• Transit peptide