Seroatlas · Human Serome Atlas

ALDH1A3

Retinaldehyde dehydrogenase 3

Also known as: AL1A3_HUMAN, ALDH6, RALDH3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P47895
Gene
ALDH1A3
Ensembl
ENSG00000184254
Chromosome
15
Canonical length
512 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Canonical amino-acid sequenceUniProt

512 residues, UniProt reviewed canonical sequence.

>P47895|ALDH1A3
     1  MATANGAVEN GQPDRKPPAL PRPIRNLEVK FTKIFINNEW HESKSGKKFA TCNPSTREQI
    61  CEVEEGDKPD VDKAVEAAQV AFQRGSPWRR LDALSRGRLL HQLADLVERD RATLAALETM
   121  DTGKPFLHAF FIDLEGCIRT LRYFAGWADK IQGKTIPTDD NVVCFTRHEP IGVCGAITPW
   181  NFPLLMLVWK LAPALCCGNT MVLKPAEQTP LTALYLGSLI KEAGFPPGVV NIVPGFGPTV
   241  GAAISSHPQI NKIAFTGSTE VGKLVKEAAS RSNLKRVTLE LGGKNPCIVC ADADLDLAVE
   301  CAHQGVFFNQ GQCCTAASRV FVEEQVYSEF VRRSVEYAKK RPVGDPFDVK TEQGPQIDQK
   361  QFDKILELIE SGKKEGAKLE CGGSAMEDKG LFIKPTVFSE VTDNMRIAKE EIFGPVQPIL
   421  KFKSIEEVIK RANSTDYGLT AAVFTKNLDK ALKLASALES GTVWINCYNA LYAQAPFGGF
   481  KMSGNGRELG EYALAEYTEV KTVTIKLGDK NP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ALDH1A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
126 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 126 nTPM
  • urinary bladder: 117 nTPM
  • salivary gland: 93 nTPM
  • adipose tissue: 79 nTPM
  • seminal vesicle: 47 nTPM
  • appendix: 39 nTPM

Single-cell type

  • salivary duct cells: 671 nCPM
  • lacrimal acinar cells: 469 nCPM
  • urothelial cells: 468 nCPM
  • salivary acinar cells: 409 nCPM
  • ocular epithelial cells: 382 nCPM
  • epicardial cells: 334 nCPM

Immune cell

  • eosinophil: 0.4 nTPM
  • basophil: 0.3 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 35 nTPM
  • cerebral cortex: 11 nTPM
  • medulla oblongata: 11 nTPM
  • cerebellum: 10 nTPM
  • white matter: 8.6 nTPM
  • thalamus: 8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ALDH1A3.

Disease | AllUniProt

Conditions ALDH1A3 is implicated in, by any mechanism.

Disease | GeneticClinVar

22 pathogenic / likely-pathogenic of 173 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.14
gnomAD missense Z
2.24
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ALDH1A3 as an antibody target. Whether an autoantibody or antibody against ALDH1A3 could matter depends on whether native ALDH1A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ALDH1A3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ALDH1A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ALDH1A3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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