Seroatlas · Human Serome Atlas

ALDH3B1

Aldehyde dehydrogenase family 3 member B1

Also known as: AL3B1_HUMAN, ALDH7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P43353
Gene
ALDH3B1
Ensembl
ENSG00000006534
Chromosome
11
Canonical length
468 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

468 residues, UniProt reviewed canonical sequence.

>P43353|ALDH3B1
     1  MDPLGDTLRR LREAFHAGRT RPAEFRAAQL QGLGRFLQEN KQLLHDALAQ DLHKSAFESE
    61  VSEVAISQGE VTLALRNLRA WMKDERVPKN LATQLDSAFI RKEPFGLVLI IAPWNYPLNL
   121  TLVPLVGALA AGNCVVLKPS EISKNVEKIL AEVLPQYVDQ SCFAVVLGGP QETGQLLEHR
   181  FDYIFFTGSP RVGKIVMTAA AKHLTPVTLE LGGKNPCYVD DNCDPQTVAN RVAWFRYFNA
   241  GQTCVAPDYV LCSPEMQERL LPALQSTITR FYGDDPQSSP NLGRIINQKQ FQRLRALLGC
   301  GRVAIGGQSD ESDRYIAPTV LVDVQEMEPV MQEEIFGPIL PIVNVQSLDE AIEFINRREK
   361  PLALYAFSNS SQVVKRVLTQ TSSGGFCGND GFMHMTLASL PFGGVGASGM GRYHGKFSFD
   421  TFSHHRACLL RSPGMEKLNA LRYPPQSPRR LRMLLVAMEA QGCSCTLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ALDH3B1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 44 nTPM
  • lung: 42 nTPM
  • fallopian tube: 37 nTPM
  • adrenal gland: 25 nTPM
  • duodenum: 22 nTPM
  • stomach: 19 nTPM

Single-cell type

  • respiratory ciliated cells: 346 nCPM
  • fallopian tube ciliated cells: 155 nCPM
  • neutrophil progenitors: 134 nCPM
  • esophageal apical cells: 123 nCPM
  • alveolar cells type 1: 78 nCPM
  • endometrial ciliated cells: 67 nCPM

Immune cell

  • eosinophil: 157 nTPM
  • intermediate monocyte: 119 nTPM
  • non-classical monocyte: 113 nTPM
  • classical monocyte: 86 nTPM
  • myeloid DC: 64 nTPM
  • basophil: 45 nTPM

Brain region

  • choroid plexus: 16 nTPM
  • white matter: 10 nTPM
  • medulla oblongata: 10 nTPM
  • midbrain: 9.1 nTPM
  • thalamus: 9.1 nTPM
  • cerebellum: 8.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1
gnomAD pLI
0
gnomAD missense Z
0.96

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ALDH3B1 as an antibody target. Whether an autoantibody or antibody against ALDH3B1 could matter depends on whether native ALDH3B1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ALDH3B1 is annotated at the cell surface, where native ALDH3B1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ALDH3B1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ALDH3B1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...