Seroatlas · Human Serome Atlas

ALDH3B2

Aldehyde dehydrogenase family 3 member B2

Also known as: AL3B2_HUMAN, ALDH8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P48448
Gene: ALDH3B2
Ensembl: ENSG00000132746
Chromosome: 11
Canonical length: 385 aa
Protein class: Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. Altered methylation patterns at this locus have been observed in spermatozoa derived from patients exhibiting reduced fecundity. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

385 residues, UniProt reviewed canonical sequence.

>P48448|ALDH3B2
     1  MKDEPRSTNL FMKLDSVFIW KEPFGLVLII APWNYPLNLT LVLLVGALAA GSCVVLKPSE
    61  ISQGTEKVLA EVLPQYLDQS CFAVVLGGPQ ETGQLLEHKL DYIFFTGSPR VGKIVMTAAT
   121  KHLTPVTLEL GGKNPCYVDD NCDPQTVANR VAWFCYFNAG QTCVAPDYVL CSPEMQERLL
   181  PALQSTITRF YGDDPQSSPN LGHIINQKQF QRLRALLGCS RVAIGGQSNE SDRYIAPTVL
   241  VDVQETEPVM QEEIFGPILP IVNVQSVDEA IKFINRQEKP LALYAFSNSS QVVNQMLERT
   301  SSGSFGGNEG FTYISLLSVP FGGVGHSGMG RYHGKFTFDT FSHHRTCLLA PSGLEKLKEI
   361  HYPPYTDWNQ QLLRWGMGSQ SCTLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ALDH3B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 158 nTPM

Expression across tissuesHPA

Tissue

esophagus: 158 nTPM
skin: 127 nTPM
breast: 68 nTPM
vagina: 43 nTPM
cervix: 35 nTPM
tonsil: 20 nTPM

Single-cell type

esophageal apical cells: 373 nCPM
esophageal suprabasal cells: 260 nCPM
esophageal basal cells: 65 nCPM
suprabasal keratinocytes: 64 nCPM
endometrial luminal cells: 62 nCPM
breast hormone-responsive cells: 57 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.3 nTPM
cerebral cortex: 0.2 nTPM
hypothalamus: 0.2 nTPM
midbrain: 0.2 nTPM
medulla oblongata: 0.1 nTPM
pons: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ALDH3B2 as an antibody target. Whether an autoantibody or antibody against ALDH3B2 could matter depends on whether native ALDH3B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ALDH3B2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ALDH3B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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