ALDH1A1

Protein identityUniProt · HPA

UniProt accession

P00352

Gene

ALDH1A1

Ensembl

ENSG00000165092

Chromosome

9

Canonical length

501 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Cytosol

Quaternary structure

Homotetramer

OverviewNCBI Gene

The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

501 residues, UniProt reviewed canonical sequence.

>P00352|ALDH1A1
     1  MSSSGTPDLP VLLTDLKIQY TKIFINNEWH DSVSGKKFPV FNPATEEELC QVEEGDKEDV
    61  DKAVKAARQA FQIGSPWRTM DASERGRLLY KLADLIERDR LLLATMESMN GGKLYSNAYL
   121  NDLAGCIKTL RYCAGWADKI QGRTIPIDGN FFTYTRHEPI GVCGQIIPWN FPLVMLIWKI
   181  GPALSCGNTV VVKPAEQTPL TALHVASLIK EAGFPPGVVN IVPGYGPTAG AAISSHMDID
   241  KVAFTGSTEV GKLIKEAAGK SNLKRVTLEL GGKSPCIVLA DADLDNAVEF AHHGVFYHQG
   301  QCCIAASRIF VEESIYDEFV RRSVERAKKY ILGNPLTPGV TQGPQIDKEQ YDKILDLIES
   361  GKKEGAKLEC GGGPWGNKGY FVQPTVFSNV TDEMRIAKEE IFGPVQQIMK FKSLDDVIKR
   421  ANNTFYGLSA GVFTKDIDKA ITISSALQAG TVWVNCYGVV SAQCPFGGFK MSGNGRELGE
   481  YGFHEYTEVK TVTVKISQKN S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ALDH1A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.21

Highest tissue expression

1,403 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ALDH1A1.

Disease | ImmuneIEDB

Conditions an epitope on ALDH1A1 was assayed in.

• skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.34

gnomAD pLI

0.95

gnomAD missense Z

1.66

DepMap mean gene effect

0.18

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• aldehyde metabolic process
• cellular detoxification of aldehyde
• gamma-aminobutyric acid biosynthetic process
• maintenance of lens transparency
• negative regulation of cold-induced thermogenesis
• retinoid metabolic process
• retinol metabolic process
• fructosamine catabolic process

Molecular functions

• acetaldehyde dehydrogenase (NAD+) activity
• aldehyde dehydrogenase (NAD+) activity
• aminobutyraldehyde dehydrogenase (NAD+) activity
• androgen binding
• benzaldehyde dehydrogenase (NAD+) activity
• GTPase activator activity
• NAD binding
• retinal dehydrogenase (NAD+) activity
• 3-deoxyglucosone dehydrogenase activity

Cellular components

• axon
• cytoplasm
• cytosol
• extracellular exosome
• synapse

Protein domainsUniProt · Pfam · InterPro

• Aldehyde dehydrogenase domain
• Aldehyde dehydrogenase, cysteine active site
• Aldehyde/histidinol dehydrogenase
• Aldehyde dehydrogenase, N-terminal
• Aldehyde dehydrogenase, C-terminal
• Aldehyde dehydrogenase, glutamic acid active site
• Aldehyde dehydrogenase family

KeywordsUniProt

• Acetylation
• Cell projection
• Cytoplasm
• Lipid metabolism
• NAD
• Nucleotide-binding
• Oxidoreductase
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of ALDH1A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PRMT3
• ALDH2