Seroatlas · Human Serome Atlas

ALDH16A1

Aldehyde dehydrogenase family 16 member A1

Also known as: A16A1_HUMAN, MGC10204

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IZ83
Gene
ALDH16A1
Ensembl
ENSG00000161618
Chromosome
19
Canonical length
802 aa
Protein class
Plasma proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the aldehyde dehydrogenase superfamily. The family members act on aldehyde substrates and use nicotinamide adenine dinucleotide phosphate (NADP) as a cofactor. This gene is conserved in chimpanzee, dog, cow, mouse, rat, and zebrafish. The protein encoded by this gene interacts with maspardin, a protein that when truncated is responsible for Mast syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

802 residues, UniProt reviewed canonical sequence.

>Q8IZ83|ALDH16A1
     1  MAATRAGPRA REIFTSLEYG PVPESHACAL AWLDTQDRCL GHYVNGKWLK PEHRNSVPCQ
    61  DPITGENLAS CLQAQAEDVA AAVEAARMAF KGWSAHPGVV RAQHLTRLAE VIQKHQRLLW
   121  TLESLVTGRA VREVRDGDVQ LAQQLLHYHA IQASTQEEAL AGWEPMGVIG LILPPTFSFL
   181  EMMWRICPAL AVGCTVVALV PPASPAPLLL AQLAGELGPF PGILNVLSGP ASLVPILASQ
   241  PGIRKVAFCG APEEGRALRR SLAGECAELG LALGTESLLL LTDTADVDSA VEGVVDAAWS
   301  DRGPGGLRLL IQESVWDEAM RRLQERMGRL RSGRGLDGAV DMGARGAAAC DLVQRFVREA
   361  QSQGAQVFQA GDVPSERPFY PPTLVSNLPP ASPCAQVEVP WPVVVASPFR TAKEALLVAN
   421  GTPRGGSASV WSERLGQALE LGYGLQVGTV WINAHGLRDP SVPTGGCKES GCSWHGGPDG
   481  LYEYLRPSGT PARLSCLSKN LNYDTFGLAV PSTLPAGPEI GPSPAPPYGL FVGGRFQAPG
   541  ARSSRPIRDS SGNLHGYVAE GGAKDIRGAV EAAHQAFPGW AGQSPGARAA LLWALAAALE
   601  RRKSTLASRL ERQGAELKAA EAEVELSARR LRAWGARVQA QGHTLQVAGL RGPVLRLREP
   661  LGVLAVVCPD EWPLLAFVSL LAPALAYGNT VVMVPSAACP LLALEVCQDM ATVFPAGLAN
   721  VVTGDRDHLT RCLALHQDVQ AMWYFGSAQG SQFVEWASAG NLKPVWASRG CPRAWDQEAE
   781  GAGPELGLRV ARTKALWLPM GD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ALDH16A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 27 nTPM
  • small intestine: 18 nTPM
  • pancreas: 18 nTPM
  • adipose tissue: 18 nTPM
  • liver: 16 nTPM
  • cervix: 16 nTPM

Single-cell type

  • enterocytes: 24 nCPM
  • hofbauer cells: 20 nCPM
  • plasma cells: 17 nCPM
  • syncytiotrophoblasts: 16 nCPM
  • medullary thymic epithelial cells: 14 nCPM
  • leydig cells: 13 nCPM

Immune cell

  • non-classical monocyte: 30 nTPM
  • intermediate monocyte: 26 nTPM
  • eosinophil: 19 nTPM
  • plasmacytoid DC: 17 nTPM
  • memory B-cell: 17 nTPM
  • naive B-cell: 17 nTPM

Brain region

  • medulla oblongata: 7.7 nTPM
  • thalamus: 7.5 nTPM
  • white matter: 6.6 nTPM
  • spinal cord: 6.4 nTPM
  • midbrain: 6.2 nTPM
  • cerebral cortex: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
-0.42
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of ALDH16A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ALDH16A1 as an antibody target. Whether an autoantibody or antibody against ALDH16A1 could matter depends on whether native ALDH16A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ALDH16A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ALDH16A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ALDH16A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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