C2H2-type Zinc-Finger Transcription Regulators
IPR050717
Definition
The protein family is characterized by members that function predominantly as transcription factors or transcriptional repressors involved in various developmental processes. These proteins play key roles in embryonic development, including heart and urogenital system formation, leg joint formation, hindgut patterning, and morphogenesis. They are also implicated in the regulation of gene expression related to H2O2 metabolism, the mitochondrial apoptotic cascade, and cellular differentiation pathways such as adipocyte differentiation and osteoblast suppression. Some family members are involved in tooth formation and kidney development. The proteins typically contain C2H2-type zinc-finger domains, which are essential for DNA-binding and transcriptional regulation, and some possess additional domains like KRAB for transcriptional repression. The family includes proteins with diverse functions across different species, unified by their structural features and roles in transcriptional regulation.
10 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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