Seroatlas · Human Serome Atlas

OSR1

Protein odd-skipped-related 1

Also known as: ODD, OSR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TAX0
Gene
OSR1
Ensembl
ENSG00000143867
Chromosome
2
Canonical length
266 aa
Protein class
Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transporter activity; positive regulation of gastrulation; and pronephros development. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

266 residues, UniProt reviewed canonical sequence.

>Q8TAX0|OSR1
     1  MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV HLHQWTLGYP
    61  AMHLPRSSFS KVPGTVSSLV DARFQLPAFP WFPHVIQPKP EITAGGSVPA LKTKPRFDFA
   121  NLALAATQED PAKLGRGEGP GSPAGGLGAL LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC
   181  GRHFTKSYNL LIHERTHTDE RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF
   241  CQSRTLAVHK TLHSQVKELK TSKIKC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OSR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
100 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 100 nTPM
  • urinary bladder: 70 nTPM
  • adipose tissue: 37 nTPM
  • salivary gland: 30 nTPM
  • cervix: 23 nTPM
  • colon: 23 nTPM

Single-cell type

  • leydig cells: 118 nCPM
  • peritubular myoid cells: 45 nCPM
  • mesothelial cells: 40 nCPM
  • salivary myoepithelial cells: 35 nCPM
  • fibroblasts: 30 nCPM
  • epicardial cells: 21 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 8 nTPM
  • choroid plexus: 4.3 nTPM
  • hippocampal formation: 3.9 nTPM
  • cerebral cortex: 3.7 nTPM
  • basal ganglia: 1.6 nTPM
  • medulla oblongata: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.86
gnomAD missense Z
1.74
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OSR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OSR1 as an antibody target. Whether an autoantibody or antibody against OSR1 could matter depends on whether native OSR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OSR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OSR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OSR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...