Seroatlas · Human Serome Atlas

ZNF182

Zinc finger protein 182

Also known as: HHZ150, KOX14, Zfp182, ZN182_HUMAN, ZNF21

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17025
Gene: ZNF182
Ensembl: ENSG00000147118
Chromosome: X
Canonical length: 639 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

639 residues, UniProt reviewed canonical sequence.

>P17025|ZNF182
     1  MTPASASGED SGSFYSWQKA KREQGLVTFE DVAVDFTQEE WQYLNPPQRT LYRDVMLETY
    61  SNLVFVGQQV TKPNLILKLE VEECPAEGKI PFWNFPEVCQ VDEQIERQHQ DDQDKCLLMQ
   121  VGFSDKKTII TKSARDCHEF GNILHLSTNL VASIQRPDKH ESFGNNMVDN LDLFSRSSAE
   181  NKYDNGCAKL FFHTEYEKTN PGMKPYGYKE CGKGLRRKKG LSLHQRIKNG EKPFECTACR
   241  KTFSKKSHLI VHWRTHTGEK PFGCTECGKA FSQKSQLIIH LRTHTGERPF ECPECGKAFR
   301  EKSTVIIHYR THTGEKPYEC NECGKAFTQK SNLIVHQKTH TGEKTYECTK CGESFIQKLD
   361  LIIHHSTHTG KKPHECNECK KTFSDKSTLI IHQRTHTGEK PHKCTECGKS FNEKSTLIVH
   421  QRTHTGEKPY ECDVCGKTFT QKSNLGVHQR THSGEKPFEC NECEKAFSQK SYLMLHQRGH
   481  TGEKPYECNE CEKAFSQKSY LIIHQRTHTE EKPYKCNECG KAFREKSKLI IHQRIHTGEK
   541  PYECPVCWKA FSQKSQLIIH QRTHTGEKPY ACTECGKAFR EKSTFTVHQR THTGEKPYKC
   601  TECGKAFTQK SNLIVHQRTH AGKKAHGRGH TRKSKFMAH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF182 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 9.5 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 9.5 nTPM
thyroid gland: 8.4 nTPM
spleen: 8.1 nTPM
pituitary gland: 7.4 nTPM
thymus: 7.1 nTPM
lymph node: 6.2 nTPM

Single-cell type

neutrophil progenitors: 15 nCPM
cardiomyocytes: 13 nCPM
thyrotrophs: 13 nCPM
neutrophils: 11 nCPM
podocytes: 11 nCPM
somatotrophs: 11 nCPM

Immune cell

non-classical monocyte: 5.5 nTPM
naive CD4 T-cell: 4.6 nTPM
memory B-cell: 4.5 nTPM
neutrophil: 4.3 nTPM
eosinophil: 4.2 nTPM
naive CD8 T-cell: 3.9 nTPM

Brain region

cerebellum: 11 nTPM
white matter: 8.8 nTPM
pons: 8 nTPM
choroid plexus: 7.9 nTPM
thalamus: 7.8 nTPM
cerebral cortex: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.98
gnomAD missense Z: 1.57
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF182 as an antibody target. Whether an autoantibody or antibody against ZNF182 could matter depends on whether native ZNF182 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF182 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF182 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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