Seroatlas · Human Serome Atlas

ZNF586

Zinc finger protein 586

Also known as: FLJ20070, ZN586_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NXT0
Gene: ZNF586
Ensembl: ENSG00000083828
Chromosome: 19
Canonical length: 402 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli fibrillar center,Vesicles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>Q9NXT0|ZNF586
     1  MAAAAALRAP AQSSVTFEDV AVNFSLEEWS LLNEAQRCLY RDVMLETLTL ISSLGCWHGG
    61  EDEAAPSKQS TCIHIYKDQG GHSGERPYEC GEYRKLFKNK SCLTEPRRDH KHRNVRTGER
   121  PYECSKYGKL FHQKPTLHIH ERFHTGQKTY ECSECGKSFH QSSSLLQRQT LHTRERPYEC
   181  IECGKAFAEK SSLINHRKVH SGAKRYECNE CGKSFAYTSS LIKHRRIHTG ERPYECSECG
   241  RSFAENSSLI KHLRVHTGER PYECVECGKS FRRSSSLLQH QRVHTRERPY ECSECGKSFS
   301  LRSNLIHHQR VHTGERHECG QCGKSFSRKS SLIIHLRVHT GERPYECSDC GKSFAENSSL
   361  IKHLRVHTGE RPYECIDCGK SFRHSSSFRR HQRVHTGMRP YK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF586 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 24 nTPM
thymus: 13 nTPM
lymph node: 11 nTPM
spleen: 9.8 nTPM
tonsil: 9.2 nTPM
skeletal muscle: 8.9 nTPM

Single-cell type

neutrophils: 309 nCPM
cardiomyocytes: 250 nCPM
myonuclei: 163 nCPM
choroid plexus epithelial cells: 137 nCPM
distal convoluted tubule cells: 122 nCPM
papillary tip epithelial cells: 112 nCPM

Immune cell

eosinophil: 32 nTPM
neutrophil: 30 nTPM
T-reg: 15 nTPM
naive CD4 T-cell: 13 nTPM
naive CD8 T-cell: 12 nTPM
memory CD4 T-cell: 11 nTPM

Brain region

cerebellum: 66 nTPM
choroid plexus: 38 nTPM
hypothalamus: 35 nTPM
cerebral cortex: 34 nTPM
white matter: 33 nTPM
hippocampal formation: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0.04
gnomAD missense Z: 0.2
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF586 as an antibody target. Whether an autoantibody or antibody against ZNF586 could matter depends on whether native ZNF586 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF586 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF586 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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