Seroatlas · Human Serome Atlas

OSR2

Protein odd-skipped-related 2

Also known as: FLJ90037, OSR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N2R0
Gene: OSR2
Ensembl: ENSG00000164920
Chromosome: 8
Canonical length: 312 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transcription factors
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

OSR2 is a mammalian homolog of the Drosophila odd-skipped family of transcription factors (Lan et al., 2004 [PubMed 15175245]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q8N2R0|OSR2
     1  MGSKALPAPI PLHPSLQLTN YSFLQAVNTF PATVDHLQGL YGLSAVQTMH MNHWTLGYPN
    61  VHEITRSTIT EMAAAQGLVD ARFPFPALPF TTHLFHPKQG AIAHVLPALH KDRPRFDFAN
   121  LAVAATQEDP PKMGDLSKLS PGLGSPISGL SKLTPDRKPS RGRLPSKTKK EFICKFCGRH
   181  FTKSYNLLIH ERTHTDERPY TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS
   241  RTLAVHKTLH MQESPHKCPT CGRTFNQRSN LKTHLLTHTD IKPYSCEQCG KVFRRNCDLR
   301  RHSLTHTPRQ DF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OSR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 162 nTPM

Expression across tissuesHPA

Tissue

endometrium: 162 nTPM
fallopian tube: 152 nTPM
cervix: 150 nTPM
ovary: 89 nTPM
vagina: 79 nTPM
seminal vesicle: 68 nTPM

Single-cell type

decidual stromal cells: 1,198 nCPM
peritubular myoid cells: 813 nCPM
leydig cells: 725 nCPM
ovarian stromal cells: 248 nCPM
extravillous trophoblasts: 228 nCPM
endometrial stromal cells: 206 nCPM

Immune cell

eosinophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 1 nTPM
cerebral cortex: 0.9 nTPM
hippocampal formation: 0.5 nTPM
amygdala: 0.4 nTPM
choroid plexus: 0.4 nTPM
pons: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0.13
gnomAD missense Z: 1.83
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OSR2 as an antibody target. Whether an autoantibody or antibody against OSR2 could matter depends on whether native OSR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OSR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OSR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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