Seroatlas · Human Serome Atlas

ZNF722

Zinc finger protein 722

Also known as: ZN722_HUMAN, ZNF722P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A1W2PQL4
Gene: ZNF722
Ensembl: ENSG00000241149
Chromosome: 7
Canonical length: 384 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

384 residues, UniProt reviewed canonical sequence.

>A0A1W2PQL4|ZNF722
     1  MAERPGSPGS REMRLLTFRD IAIEFSLEEW QCLDCAQQNL YRDVMLENYR NLVSLGIADS
    61  KPDLITCLEQ NKEAWNIKRN EMVAKHPVTC SHFTQDLHPE QGIKHSLQKV IPRTYGKCGH
   121  ENLQFKKCCK SVGECEVHKG GYNEVKQCLS NTQNKIFQTH KCVIVFGKFS NCNRHETRYT
   181  GKKHFKCKKY GKSFCMPSHL NQHQIIHTKE KSYKCEECGK SFKRSSNCTT HKRIHTGEKP
   241  YRCEECGKAF RWPSNLTRHK RIHTGEKPYT CEECGQAFRR SSTLTNHKRI HTGERPYKCE
   301  ECGKAFSVSS TLNDHKRIHT GEKPYTCEEC GRAFNCSSTL KTHKRIHTGE KPYKCEECDK
   361  AFKRHSSLAK HKIIHTGEKP YKSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF722 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 1.6 nTPM

Expression across tissuesHPA

Tissue

testis: 1.6 nTPM
bone marrow: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

differentiating spermatogonia: 17 nCPM
late primary spermatocytes: 10 nCPM
early primary spermatocytes: 8.1 nCPM
early spermatids: 5.6 nCPM
undifferentiated spermatogonia: 4.1 nCPM
epicardial cells: 2.3 nCPM

Immune cell

basophil: 0.5 nTPM
neutrophil: 0.4 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

white matter: 1.5 nTPM
medulla oblongata: 1.4 nTPM
pons: 1.3 nTPM
cerebral cortex: 1.2 nTPM
cerebellum: 1.1 nTPM
thalamus: 1.1 nTPM

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF722 as an antibody target. Whether an autoantibody or antibody against ZNF722 could matter depends on whether native ZNF722 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF722 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF722 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...