Seroatlas · Human Serome Atlas

ZNF358

Zinc finger protein 358

Also known as: FLJ10390, ZFEND, ZN358_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NW07
Gene
ZNF358
Ensembl
ENSG00000198816
Chromosome
19
Canonical length
568 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including embryonic forelimb morphogenesis; neural tube development; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

568 residues, UniProt reviewed canonical sequence.

>Q9NW07|ZNF358
     1  MRRSVLVRNP GHKGLRPVYE ELDSDSEDLD PNPEDLDPVS EDPEPDPEDL NTVPEDVDPS
    61  YEDLEPVSED LDPDAEAPGS EPQDPDPMSS SFDLDPDVIG PVPLILDPNS DTLSPGDPKV
   121  DPISSGLTAT PQVLATSPAV LPAPASPPRP FSCPDCGRAF RRSSGLSQHR RTHSGEKPYR
   181  CPDCGKSFSH GATLAQHRGI HTGARPYQCA ACGKAFGWRS TLLKHRSSHS GEKPHHCPVC
   241  GKAFGHGSLL AQHLRTHGGP RPHKCPVCAK GFGQGSALLK HLRTHTGERP YPCPQCGKAF
   301  GQSSALLQHQ RTHTAERPYR CPHCGKAFGQ SSNLQHHLRI HTGERPYACP HCSKAFGQSS
   361  ALLQHLHVHS GERPYRCQLC GKAFGQASSL TKHKRVHEGA AAAAAAAAAA AAAAAAGLGL
   421  GPGLSPASMM RPGQVSLLGP DAVSVLGSGL GLSPGTSSGR NPDPGSGPGT LPDPSSKPLP
   481  GSRSTPSPTP VESSDPKAGH DAGPDLVPSP DLDPVPSPDP DPVPSPDPNP VSCPDPCSPT
   541  RGTVSPALPT GESPEWVQEQ GALLGPDG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF358 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
165 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 165 nTPM
  • cerebral cortex: 140 nTPM
  • tongue: 137 nTPM
  • amygdala: 115 nTPM
  • hippocampal formation: 107 nTPM
  • heart muscle: 102 nTPM

Single-cell type

  • hepatic stellate cells: 58 nCPM
  • salivary acinar cells: 56 nCPM
  • epididymal efferent duct absorptive cells: 55 nCPM
  • smooth muscle cells: 51 nCPM
  • hepatocytes: 50 nCPM
  • granulosa cells: 45 nCPM

Immune cell

  • basophil: 1.5 nTPM
  • naive B-cell: 0.7 nTPM
  • naive CD8 T-cell: 0.7 nTPM
  • gdT-cell: 0.6 nTPM
  • classical monocyte: 0.5 nTPM
  • intermediate monocyte: 0.5 nTPM

Brain region

  • cerebral cortex: 135 nTPM
  • thalamus: 133 nTPM
  • midbrain: 119 nTPM
  • amygdala: 117 nTPM
  • hippocampal formation: 111 nTPM
  • white matter: 110 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.79
gnomAD missense Z
2.58
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF358 as an antibody target. Whether an autoantibody or antibody against ZNF358 could matter depends on whether native ZNF358 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF358 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF358 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF358. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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