ZNF467

Protein identityUniProt · HPA

UniProt accession

Q7Z7K2

Gene

ZNF467

Ensembl

ENSG00000181444

Chromosome

7

Canonical length

595 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Mitochondria

OverviewNCBI Gene

The protein encoded by this gene is a zinc finger protein whose function has not yet been elucidated in humans. However, the mouse ortholog of this protein enhances adipocyte differentiation and suppresses osteoblast differentiation in bone marrow. The mouse protein also is a transcription factor for several genes and can help recruit histone deacetylase complexes. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

595 residues, UniProt reviewed canonical sequence.

>Q7Z7K2|ZNF467
     1  MRETLEALSS LGFSVGQPEM APQSEPREGS HNAQEQMSSS REERALGVCS GHEAPTPEEG
    61  AHTEQAEAPC RGQACSAQKA QPVGTCPGEE WMIRKVKVED EDQEAEEEVE WPQHLSLLPS
   121  PFPAPDLGHL AAAYKLEPGA PGALSGLALS GWGPMPEKPY GCGECERRFR DQLTLRLHQR
   181  LHRGEGPCAC PDCGRSFTQR AHMLLHQRSH RGERPFPCSE CDKRFSKKAH LTRHLRTHTG
   241  ERPYPCAECG KRFSQKIHLG SHQKTHTGER PFPCTECEKR FRKKTHLIRH QRIHTGERPY
   301  QCAQCARSFT HKQHLVRHQR VHQTAGPARP SPDSSASPHS TAPSPTPSFP GPKPFACSDC
   361  GLSFGWKKNL ATHQCLHRSE GRPFGCDECA LGATVDAPAA KPLASAPGGP GCGPGSDPVV
   421  PQRAPSGERS FFCPDCGRGF SHGQHLARHP RVHTGERPFA CTQCDRRFGS RPNLVAHSRA
   481  HSGARPFACA QCGRRFSRKS HLGRHQAVHT GSRPHACAVC ARSFSSKTNL VRHQAIHTGS
   541  RPFSCPQCGK SFSRKTHLVR HQLIHGEAAH AAPDAALAAP AWSAPPEVAP PPLFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF467 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.54

Highest tissue expression

22 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.27

gnomAD pLI

0

gnomAD missense Z

0.24

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• zinc ion binding

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• Zinc finger C2H2-type
• Zinc finger C2H2 superfamily
• C2H2-type Zinc-Finger Transcription Regulators
• Zinc finger, C2H2 type

KeywordsUniProt

• DNA-binding
• Isopeptide bond
• Metal-binding
• Nucleus
• Repeat
• Transcription
• Transcription regulation
• Ubl conjugation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ZNF467 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• STAT3