ADAMTS and ADAMTS-like
IPR050439
Definition
The ADAMTS and ADAMTS-like protein family is involved in various biological processes, including the regulation of extracellular matrix (ECM) composition, cell migration, development, and apoptosis. Members of this family are metalloproteinases that cleave components such as aggrecan and versican, contributing to ECM remodeling. Some proteins within this family have a role in inhibiting angiogenesis, while others facilitate microfibril biogenesis and influence tissue organization. The family includes proteins with thrombospondin type-1 motifs, which are important for ECM interaction, and some members possess a cysteine-switch motif that regulates their enzymatic activity. Additionally, certain ADAMTS-like proteins may have protease-independent functions in cellular processes such as ER to Golgi transport.
26 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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