Homeobox NK-like transcription regulators
IPR050394
Definition
This family of proteins includes transcription factors that play critical roles in embryonic development and organogenesis. Members are involved in the specification and differentiation of various cell types, particularly within the central nervous system, heart, thyroid, lungs, and pancreas. They are characterized by their ability to bind DNA and regulate the expression of target genes, which influences processes such as neuron development, heart formation, and insulin production. Some proteins within this family act as transcriptional activators, while others function as repressors. They are also implicated in the maintenance of energy homeostasis and may have tumor suppressor functions.
14 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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