Seroatlas · Human Serome Atlas

NKX1-1

NK1 transcription factor-related protein 1

Also known as: HSPX153, NKX11_HUMAN, SAX2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15270
Gene: NKX1-1
Ensembl: ENSG00000235608
Chromosome: 4
Canonical length: 448 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

This gene encodes a transcription factor that belongs to NKX family of homeodomain-containing proteins which are critical regulators of organ development. In mice, the orthologous gene is expressed predominantly in the brainstem, in the vicinity of serotonergic neurons, and is required for the coordinated crosstalk of factors involved in the maintenance of energy homeostasis. Mice with a knockout of the orthologous gene lack subcutaneous fat and intra-abdominal epididymal and mesenteric white adipose tissue two weeks after birth, and die within three weeks after birth. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

448 residues, UniProt reviewed canonical sequence.

>Q15270|NKX1-1
     1  MSASGPEAPG DIPALPPPPQ PGSGPAPPAP AAAAQEAMDG RAELPAFPRA GAPPLAASDT
    61  VPAAPEGAGA ARPAAPLRPT SFSVLDILDP NKFNSRRRRC VLLGPVAPAA CAPCASAPCA
   121  PAPAASGRPP RAEELERRAL AGAGGVGAAG AEPPNAGDPF KAGEAETNDT NGYSSGGGGH
   181  SPSADSGDEV PDDEDDDEDE APETEAARGA EEARGGGGGL GARGSGCQGA AETDASPGAT
   241  VDEAAAPGPR ENSPVAQGPP GGAAAPGGAG TTPQGTATAA KPKRKRTGSD SKSGKPRRAR
   301  TAFTYEQLVA LENKFKATRY LSVCERLNLA LSLSLTETQV KIWFQNRRTK WKKQNPGADT
   361  SAPTGGGGGP GPGAGPGTGL PGGLSPLSPS PPMGAPLGMH GPAGYPAHGP GGLVCAAQLP
   421  FLSSPAVLSP FVLGSQTYGA PAFYAPHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NKX1-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 0.4 nTPM

Expression across tissuesHPA

Tissue

testis: 0.4 nTPM
pituitary gland: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

late spermatids: 0.9 nCPM
early spermatids: 0.7 nCPM
late primary spermatocytes: 0.7 nCPM
undifferentiated spermatogonia: 0.2 nCPM
corticotrophs: 0.1 nCPM
adipocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 1.6 nTPM
pons: 1.3 nTPM
spinal cord: 0.7 nTPM
white matter: 0.3 nTPM
midbrain: 0.1 nTPM
amygdala: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.71
gnomAD missense Z: 0.74

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NKX1-1 as an antibody target. Whether an autoantibody or antibody against NKX1-1 could matter depends on whether native NKX1-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NKX1-1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NKX1-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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