Seroatlas · Human Serome Atlas

NKX2-3

Homeobox protein Nkx-2.3

Also known as: CSX3, NKX2.3, NKX23_HUMAN, NKX2C, NKX4-3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAU0
Gene: NKX2-3
Ensembl: ENSG00000119919
Chromosome: 10
Canonical length: 364 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli,Cytosol

OverviewNCBI Gene

This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiation.[provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>Q8TAU0|NKX2-3
     1  MMLPSPVTST PFSVKDILNL EQQHQHFHGA HLQADLEHHF HSAPCMLAAA EGTQFSDGGE
    61  EDEEDEGEKL SYLNSLAAAD GHGDSGLCPQ GYVHTVLRDS CSEPKEHEEE PEVVRDRSQK
   121  SCQLKKSLET AGDCKAAEES ERPKPRSRRK PRVLFSQAQV FELERRFKQQ RYLSAPEREH
   181  LASSLKLTST QVKIWFQNRR YKCKRQRQDK SLELGAHAPP PPPRRVAVPV LVRDGKPCVT
   241  PSAQAYGAPY SVGASAYSYN SFPAYGYGNS AAAAAAAAAA AAAAAAYSSS YGCAYPAGGG
   301  GGGGGTSAAT TAMQPACSAA GGGPFVNVSN LGGFGSGGSA QPLHQGTAAG AACAQGTLQG
   361  IRAW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NKX2-3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

colon: 35 nTPM
spleen: 28 nTPM
small intestine: 21 nTPM
salivary gland: 14 nTPM
duodenum: 10 nTPM
rectum: 4.4 nTPM

Single-cell type

salivary ionocytes: 25 nCPM
salivary basal cells: 24 nCPM
hematopoietic stem cells: 13 nCPM
vascular endothelial cells: 8.1 nCPM
basal keratinocytes: 5.1 nCPM
salivary duct cells: 5 nCPM

Immune cell

memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 0.2 nTPM
medulla oblongata: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.95
gnomAD missense Z: 0.81
DepMap mean gene effect: 0.02
DepMap dependency class: none

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NKX2-3 as an antibody target. Whether an autoantibody or antibody against NKX2-3 could matter depends on whether native NKX2-3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NKX2-3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NKX2-3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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