Seroatlas · Human Serome Atlas

NKX1-2

NK1 transcription factor-related protein 2

Also known as: bB238F13.2, C10orf121, NKX12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UD57
Gene: NKX1-2
Ensembl: ENSG00000229544
Chromosome: 10
Canonical length: 310 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>Q9UD57|NKX1-2
     1  MLAWQDGGAK AAPSHHKISF SVLDILDPQK FTRAALPAVR PAPREARKSL AEVEAGKDAS
    61  SRDPVRQLET PDAAGPGAGQ ASPLEGSEAE EEEDAEDPRR PRLRERAARL LPGLARSPDA
   121  PAGALASGEP CEDGGGGPVR SPPGSPGSPR PRRRRLEPNC AKPRRARTAF TYEQLVALEN
   181  KFRATRYLSV CERLNLALSL SLTETQVKIW FQNRRTKWKK QNPGADGAAQ VGGGAPQPGA
   241  AGGGGGGGSG GSPGPPGTGA LHFQTFPSYS AANVLFPSAA SFPLTAAAPG SPFAPFLGPS
   301  YLTPFYAPRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NKX1-2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 0.5 nTPM

Expression across tissuesHPA

Tissue

esophagus: 0.5 nTPM
basal ganglia: 0.4 nTPM
cerebral cortex: 0.4 nTPM
small intestine: 0.4 nTPM
skin: 0.3 nTPM
vagina: 0.3 nTPM

Single-cell type

basal keratinocytes: 2.1 nCPM
respiratory basal cells: 2.1 nCPM
breast secretory cells: 1.1 nCPM
lacrimal acinar cells: 0.9 nCPM
respiratory secretory cells: 0.8 nCPM
esophageal basal cells: 0.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 1.6 nTPM
cerebral cortex: 1.1 nTPM
white matter: 0.8 nTPM
thalamus: 0.7 nTPM
hippocampal formation: 0.5 nTPM
medulla oblongata: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.71
gnomAD pLI: 0
gnomAD missense Z: -0.22
DepMap mean gene effect: -0.07
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NKX1-2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HIPK2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NKX1-2 as an antibody target. Whether an autoantibody or antibody against NKX1-2 could matter depends on whether native NKX1-2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NKX1-2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NKX1-2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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