NKX2-2

Protein identityUniProt · HPA

UniProt accession

O95096

Gene

NKX2-2

Ensembl

ENSG00000125820

Chromosome

20

Canonical length

273 aa

Protein class

Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

273 residues, UniProt reviewed canonical sequence.

>O95096|NKX2-2
     1  MSLTNTKTGF SVKDILDLPD TNDEEGSVAE GPEEENEGPE PAKRAGPLGQ GALDAVQSLP
    61  LKNPFYDSSD NPYTRWLAST EGLQYSLHGL AAGAPPQDSS SKSPEPSADE SPDNDKETPG
   121  GGGDAGKKRK RRVLFSKAQT YELERRFRQQ RYLSAPEREH LASLIRLTPT QVKIWFQNHR
   181  YKMKRARAEK GMEVTPLPSP RRVAVPVLVR DGKPCHALKA QDLAAATFQA GIPFSAYSAQ
   241  SLQHMQYNAQ YSSASTPQYP TAHPLVQAQQ WTW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NKX2-2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.63

Highest tissue expression

42 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.67

gnomAD pLI

0.41

gnomAD missense Z

0

DepMap mean gene effect

0.11

DepMap dependency class

none

OntologyGO

Biological processes

• astrocyte differentiation
• brain development
• cell differentiation
• digestive tract development
• negative regulation of neuron differentiation
• neuroendocrine cell differentiation
• neuron fate specification
• oligodendrocyte development
• optic nerve development
• pancreatic A cell fate commitment
• pancreatic PP cell fate commitment
• positive regulation of epithelial cell differentiation
• positive regulation of gene expression
• positive regulation of neuron differentiation
• positive regulation of oligodendrocyte differentiation
• regulation of transcription by RNA polymerase II
• response to glucose
• response to progesterone
• smoothened signaling pathway
• spinal cord motor neuron differentiation
• spinal cord oligodendrocyte cell fate specification
• type B pancreatic cell development
• type B pancreatic cell fate commitment
• ventral spinal cord interneuron fate determination

Molecular functions

• cis-regulatory region sequence-specific DNA binding
• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding

Cellular components

• chromatin
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Homeodomain
• Homedomain-like superfamily
• Homeobox, conserved site
• Homeodomain, metazoa
• Homeobox NK-like transcription regulators
• Homeodomain

KeywordsUniProt

• Activator
• Developmental protein
• DNA-binding
• Homeobox
• Nucleus
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of NKX2-2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• OLIG2