Semaphorin
IPR027231
Definition
Semaphorins are a family of cell surface and soluble proteins originally identified as axon guidance factors, but are now recognised to to be involved in a wide range of functions, including neural connectivity, angiogenesis, immunoregulation, and cancer [[cite:PMID:16584533], [cite:PMID:22897846], [cite:PMID:22157652], [cite:PMID:22895477]]. Some semaphorins have an important role in the immune response, some regulate immune cell activation or differentiation, while others regulate the trafficking of immune cells PMID:22325954. Semaphorins signal through two major receptor families, plexins and neuropilins (Nrps). All semaphorins have a Sema domain, characterised by a seven-blade β propeller structure, which contains sites for semaphorin dimerisation and receptor binding. Semaphorins are grouped into eight classes based on their structural domains, with classes 3-7 comprising the vertebrate semaphorins PMID:22157652.
20 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...