Seroatlas · Human Serome Atlas

SEMA6C

Semaphorin-6C

Also known as: KIAA1869, SEM6C_HUMAN, Sema-Y

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H3T2
Gene
SEMA6C
Ensembl
ENSG00000143434
Chromosome
1
Canonical length
930 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the semaphorin family. Semaphorins represent important molecular signals controlling multiple aspects of the cellular response that follows CNS injury, and thus may play an important role in neural regeneration. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

930 residues, UniProt reviewed canonical sequence.

>Q9H3T2|SEMA6C
     1  MPRAPHFMPL LLLLLLLSLP HTQAAFPQDP LPLLISDLQG TSPLSWFRGL EDDAVAAELG
    61  LDFQRFLTLN RTLLVAARDH VFSFDLQAEE EGEGLVPNKY LTWRSQDVEN CAVRGKLTDE
   121  CYNYIRVLVP WDSQTLLACG TNSFSPVCRS YGITSLQQEG EELSGQARCP FDATQSNVAI
   181  FAEGSLYSAT AADFQASDAV VYRSLGPQPP LRSAKYDSKW LREPHFVQAL EHGDHVYFFF
   241  REVSVEDARL GRVQFSRVAR VCKRDMGGSP RALDRHWTSF LKLRLNCSVP GDSTFYFDVL
   301  QALTGPVNLH GRSALFGVFT TQTNSIPGSA VCAFYLDEIE RGFEGKFKEQ RSLDGAWTPV
   361  SEDRVPSPRP GSCAGVGGAA LFSSSRDLPD DVLTFIKAHP LLDPAVPPVT HQPLLTLTSR
   421  ALLTQVAVDG MAGPHSNITV MFLGSNDGTV LKVLTPGGRS GGPEPILLEE IDAYSPARCS
   481  GKRTAQTARR IIGLELDTEG HRLFVAFSGC IVYLPLSRCA RHGACQRSCL ASQDPYCGWH
   541  SSRGCVDIRG SGGTDVDQAG NQESMEHGDC QDGATGSQSG PGDSAYGVRR DLPPASASRS
   601  VPIPLLLASV AAAFALGASV SGLLVSCACR RAHRRRGKDI ETPGLPRPLS LRSLARLHGG
   661  GPEPPPPSKD GDAVQTPQLY TTFLPPPEGV PPPELACLPT PESTPELPVK HLRAAGDPWE
   721  WNQNRNNAKE GPGRSRGGHA AGGPAPRVLV RPPPPGCPGQ AVEVTTLEEL LRYLHGPQPP
   781  RKGAEPPAPL TSRALPPEPA PALLGGPSPR PHECASPLRL DVPPEGRCAS APARPALSAP
   841  APRLGVGGGR RLPFSGHRAP PALLTRVPSG GPSRYSGGPG KHLLYLGRPE GYRGRALKRV
   901  DVEKPQLSLK PPLVGPSSRQ AVPNGGRFNF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEMA6C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
263 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 263 nTPM
  • tongue: 85 nTPM
  • cerebellum: 46 nTPM
  • heart muscle: 37 nTPM
  • testis: 31 nTPM
  • ovary: 14 nTPM

Single-cell type

  • myonuclei: 181 nCPM
  • sertoli cells: 75 nCPM
  • thymic myoid cells: 52 nCPM
  • proximal tubule cells: 43 nCPM
  • granulosa cells: 41 nCPM
  • retinal amacrine cells: 17 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 51 nTPM
  • cerebral cortex: 26 nTPM
  • basal ganglia: 23 nTPM
  • thalamus: 23 nTPM
  • hippocampal formation: 21 nTPM
  • amygdala: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0
gnomAD missense Z
1.59
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEMA6C as an antibody target. Whether an autoantibody or antibody against SEMA6C could matter depends on whether native SEMA6C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEMA6C is annotated at the cell surface, where native SEMA6C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SEMA6C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SEMA6C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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